Results 121 to 130 of about 5,482,674 (247)
Advanced Science, EarlyView.Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan +10 more
wiley +1 more source
Advanced Science, EarlyView.Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
Spatiotemporal topography of the BAM complex in relation to peptidoglycan and cell division
, 2022 Gram-negative bacteria possess a three-layered envelope composed of two concentric membranes, the inner membrane and the outer membrane (OM). In-between an aqueous space called the periplasm that contains the peptidoglycan (PG) layer. The envelope ensures protection against diverse hostile environments and offers an effective barrier against ...
openaire +1 more source
Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli
eLifeBiogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic resistance. Central to this is the β-barrel assembly machine (Bam) complex and its associated chaperones, which are responsible for transport, folding, and insertion ...
Jack A Bryant +17 more
doaj +1 more source
Advanced Science, EarlyView.MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant +14 more
wiley +1 more source
Bypassing BamD essentiality by mutations in a non-essential substrate
mBioThe β-barrel assembly machinery (Bam) is essential for assembling all transmembrane β-barrel outer membrane proteins in gram-negative bacteria. The Bam complex consists of the central β-barrel protein BamA and accessory Bam lipoproteins, including the ...
Santosh Kumar, Anna Konovalova
doaj +1 more source
Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery
Advanced Science, EarlyView.A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li +9 more
wiley +1 more source
BAM UPDATE #1/2024 BAM Update (Rights reserved) (-) Ausgabe 4/2025 BAM Update #4/2025 (-) Ausgabe 3/2025 BAM Update #3/2025 (-) Ausgabe 2/2025 BAM Update #2/2025 (-) Ausgabe 1/2025 BAM Update #1/2025 (-) Ausgabe 6/2024 BAM ...
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