Results 221 to 230 of about 130,114 (271)

Analytical Validation of an Annotation Tool for WGS-Based Pharmacogenomics: Preparing for Clinical Implementation in Pediatric Oncology. [PDF]

Clin Transl Sci
Diekstra MHM, Biesot N, Donders J, Verwiel ETP, Janse A, Huitema ADR, Hanff LM, Tops BBJ, Kemmeren P, Hehir-Kwa JY.   +9 more
europepmc   +1 more source

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

Advanced Science, EarlyView.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang, Jiahao Li, Zhuying Yue, Beixuan He, Wenhua Zhang, Zhen Fang, Qing Xia, Yingbin Liu, Yanjing Li   +8 more
wiley   +1 more source

Metapipeline-DNA: A comprehensive germline and somatic genomics Nextflow pipeline. [PDF]

Cell Rep Methods
Patel Y, Zhu C, Yamaguchi TN, Wang NK, Wiltsie N, Zeltser N, Gonzalez AE, Winata HK, Pan Y, Mootor MFE, Sanders T, Fitz-Gibbon ST, Kandoth C, Livingstone J, Liu LY, Carlin B, Holmes A, Oh J, Sahrmann J, Tao S, Eng S, Hugh-White R, Pashminehazar K, Beshlikyan A, Jordan M, Wu S, Tian M, Arbet J, Neilsen B, Haas R, Bugh YZ, Kim G, Salmingo J, Zhang W, Anand A, Hwang E, Neiman-Golden A, Steinberg P, Zhao W, Anand P, Agrawal R, Tsai BL, Boutros PC.   +42 more
europepmc   +1 more source

Isosteric Substitution Enables Rational Design of Two‐Dimensional Energetic Crystals

Advanced Science, EarlyView.
Isosteric substitution transforms a classical nitro–amine motif into two‐dimensional aminofurazans with performance beyond TATB. ABSTRACT Two‐dimensional (2D) energetic crystals dissipate mechanical insult via interlayer slip, yet their molecular design space remains narrow.
Linyuan Wen, Wentong Tu, Tao Yu, Chao Chen, Zhixiang Zhang, Zhixiang Xie, Yingzhe Liu   +6 more
wiley   +1 more source

Direct neuronal reprogramming: emerging therapeutic strategies for neurodegenerative disorders. [PDF]

Ann Med
Tyagi A, Prabhu V, Agarwal P, Kumar P.
europepmc   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Patient Characteristics and Clinical Outcomes of Acute Pyelonephritis Treated in Mayo Clinic's Hospital-at-Home Program. [PDF]

Open Forum Infect Dis
Gomez-Cabello CA, Dumic I, Maniaci MJ, Paulson MR, Shiari A, Webster LW, McGrew J, Genovese A, Collaco B, Trabilsy M, Forte AJ, Bosch W.   +11 more
europepmc   +1 more source

CRISPR/Cas13a: Compensatory Target Activation Mechanism

Advanced Science, EarlyView.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang, Tenghua Zhang, Yao Lu, Shujun Zhou, Wenjing Xiao, Shuming Pan, Nan Shi, Yan Sheng, Jiaming Hu   +8 more
wiley   +1 more source

Artificial Intelligence Powers Protein Functional Annotation

Advanced Science, EarlyView.
This review systematically summarizes how artificial intelligence advances protein functional annotation. It organizes existing methods into six unified modeling paradigms and analyzes their applications in Gene Ontology and Enzyme Commission prediction.
Wenkang Wang, Qiurong Yang, Min Zeng, Ruiqing Zheng, Min Li   +4 more
wiley   +1 more source

MYCBP interacts with Sakura and Otu and is essential for germline stem cell renewal and differentiation and oogenesis. [PDF]

PLoS Genet
Azlan A, Fukunaga R.
europepmc   +1 more source