Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model [PDF]
Frontiers in Physiology, 2023 Red blood cells (RBCs) undergo metabolic, oxidative, and physiological changes during storage, collectively described as the “storage lesion.” The impact of storage on oxygen homeostasis, following transfusion, is not fully understood.
Sirsendu Jana +4 more
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Proteomics of Stored Red Blood Cell Membrane and Storage-Induced Microvesicles Reveals the Association of Flotillin-2 With Band 3 Complexes [PDF]
Frontiers in Physiology, 2018 The storage of erythrocyte concentrates (ECs) induces lesions that notably affect metabolism, protein activity, deformability of red blood cells (RBCs), as well as the release of oxygen.
Michel Prudent +8 more
doaj +3 more sources
Particle Simulation of Oxidation Induced Band 3 Clustering in Human Erythrocytes. [PDF]
PLoS Computational Biology, 2015 Oxidative stress mediated clustering of membrane protein band 3 plays an essential role in the clearance of damaged and aged red blood cells (RBCs) from the circulation.
Hanae Shimo +7 more
doaj +3 more sources
Interaction of the human erythrocyte Band 3 anion exchanger 1 (AE1, SLC4A1) with lipids and glycophorin A: Molecular organization of the Wright (Wr) blood group antigen. [PDF]
PLoS Computational Biology, 2018 The Band 3 (AE1, SLC4A1) membrane protein is found in red blood cells and in kidney where it functions as an electro-neutral chloride/bicarbonate exchanger.
Antreas C Kalli, Reinhart A F Reithmeier
doaj +3 more sources
Band 3–mediated Plasmodium vivax invasion is associated with transcriptional variation in PvTRAg genes [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 The Plasmodium vivax reticulocyte invasion process is still poorly understood, with only a few receptor-ligand interactions identified to date. Individuals with the Southeast Asian ovalocytosis (SAO) phenotype have a deletion in the band 3 protein on the
Katlijn De Meulenaere +17 more
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Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1.
Am J Physiol Cell Physiol, 2021 The major transmembrane protein of the red blood cell, known as band 3, AE1, and SLC4A1, has two main functions: 1) catalysis of Cl−/HCO3− exchange, one of the steps in CO2 excretion, and 2) anchoring the membrane skeleton. This review summarizes the 150-
Jennings ML.
europepmc +2 more sources
Different Involvement of Band 3 in Red Cell Deformability and Osmotic Fragility—A Comparative GP.Mur Erythrocyte Study [PDF]
Cells, 2021 GP.Mur is a clinically important red blood cell (RBC) phenotype in Southeast Asia. The molecular entity of GP.Mur is glycophorin B-A-B hybrid protein that promotes band 3 expression and band 3–AQP1 interaction, and alters the organization of band 3 ...
Mei-Shin Kuo +5 more
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Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease. [PDF]
Br J Haematol, 2020 Many hypotheses have been proposed to explain how a glutamate to valine substitution in sickle haemoglobin (HbS) can cause sickle cell disease (SCD). We propose and document a new mechanism in which elevated tyrosine phosphorylation of Band 3 initiates ...
Noomuna P +12 more
europepmc +2 more sources
High Glucose Concentrations Affect Band 3 Protein in Human Erythrocytes [PDF]
Antioxidants, 2020 Hyperglycemia is considered a threat for cell homeostasis, as it is associated to oxidative stress (OS). As erythrocytes are continuously exposed to OS, this study was conceived to verify the impact of either diabetic conditions attested to by glycated ...
Rossana Morabito +6 more
doaj +2 more sources
Haematologica, 2015 Band 3 is the most abundant protein in the erythrocyte membrane and forms the core of a major multiprotein complex. The absence of band 3 in human erythrocytes has only been reported once, in the homozygous band 3 Coimbra patient.
Timothy J Satchwell +4 more
doaj +2 more sources