Results 71 to 80 of about 2,427,062 (292)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

open access: yesFEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Business Cycle Estimation with High-Pass and Band-Pass Local Polynomial Regression

open access: yesEconometrics, 2017
Filters constructed on the basis of standard local polynomial regression (LPR) methods have been used in the literature to estimate the business cycle.
Luis J. Álvarez
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach   +23 more
wiley   +1 more source

Fast calculation algorithm for discrete resonance-based band-pass filter

open access: yesAlexandria Engineering Journal, 2016
A discrete resonant band-pass filter with a fast calculation algorithm, which can be used to perform discrete frequency transformations, is presented. The algorithm has low memory consumption requirements.
Toso Pankovski
doaj   +1 more source

Direct Synthesis of Quad-Band Band-Pass Filter by Frequency Transformation Methods

open access: yes, 2019
International audienceThis article presents a method to design a quad-band band-pass filter. It is based on a frequency transformation function allowing the direct transformation of a low-pass prototype in a quad-band band-pass filter.
Quendo, Cédric   +3 more
core  

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie   +8 more
wiley   +1 more source

Compact band-pass electromechanical filter

open access: yesТехнологія та конструювання в електронній апаратурі, 2003
A comparison is presented between the characteristics of the proposed compact electromechanical filter in monolithic design and filters produced by Rockwell Collins.
Yu. E. Paerand
doaj  

Applying the Hirose-Kamada filter to Swiss data: Output gap and exchange rate pass-through estimates [PDF]

open access: yes
Multivariate filters based on the Hodrick-Prescott filter are appealing because they combine the advantages of the Hodrick-Prescott filter with economic relationships.
Enzo Rossi, Franziska Bignasca
core  

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias   +3 more
wiley   +1 more source

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