Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Effective band selection of hyperspectral image by an attention mechanism-based convolutional network. [PDF]
RSC Adv, 2022 Zheng Z +5 more
europepmc +1 more source
Global attentional selection of visual features is not associated with selective modulation of posterior alpha‐band activity [PDF]
, 2023 Christopher Gundlach +2 more
openalex +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Automated speech emotion polarization for a distance education system based on orbital local binary pattern and an appropriate sub-band selection technique. [PDF]
Multimed Tools Appl, 2023 Tanko D +4 more
europepmc +1 more source
The 2dF Galaxy Redshift Survey: the bJ-band galaxy luminosity function and survey selection function [PDF]
, 2002 P. Norberg +28 more
openalex +1 more source
A Dual-band Metasurface with Extreme Angular-Asymmetric Transmission and Frequency Selection Based on Resonant Coupling Effect [PDF]
, 2022 Yidan Wang +7 more
openalex +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source