Results 111 to 120 of about 666,483 (294)

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Snapshot Spatiotemporal‐Spectral Imaging Enabled by Joint Photonic Encoding

Advanced Science, EarlyView.
Spectra4D enables snapshot spatiotemporal‐spectral imaging by combining high‐speed DMD temporal modulation with CMOS‐integrated Fabry‐Pérot spectral encoding. From a single 2D measurement, a dual‐mask‐guided reconstruction network recovers multiple time‐resolved hyperspectral frames, enabling high‐fidelity observation of rapidly evolving spatial ...
Chunyu Chen, Junren Wen, Hao Sha, Chenying Yang, Ziyang Chen, Xiaochen Feng, Taiqin Chen, Wenzhen Zou, Xiangyu Chen, Xiangyang Ji, Guojun Liu, Yongbing Zhang   +11 more
wiley   +1 more source

Are Business Cycles All Alike? A Bandpass Filter Analysis of Italian and US Cycles [PDF]

In this paper, we apply the bandpass filter to the main Italian and US macroeconomic variables, we estimate cross-correlations with respect to a benchmark indicator of the business cycle, and we compare results with previous empirical analyses.
Mauro Napoletano, Sandro Sapio, Andrea Roventini   +2 more
core  

A Multimodal Intelligent System for Human Digital Twin Simulation with Continuous Kinematic Data Tracking, Biometric Prognosis, and Cognitive State Feedback in Industrial Environments

Advanced Intelligent Discovery, EarlyView.
This article implements a unified human digital twin framework that integrates cutting edge actuation, sensing, simulation, and bidirectional feedback capability. The approach includes integrating multimodal sensing, AI, and biomechanical simulation into one compact system.
Tajbeed Ahmed Chowdhury, Sebastian Gratz‐Kelly, Eric Wagner, Paul Motzki, Martina Lehser   +4 more
wiley   +1 more source

A High‐Precision Dynamic Movement Recognition Algorithm Using Multimodal Biological Signals for Human–Machine Interaction

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This article describes a multimodal fusion data acquisition and processing system about electromyography for dynamic movement recognition and bioelectrical impedance for key posture recognition. In addition, a new dynamic–static fusion algorithm strategy is designed.
Chenhao Cao, Gang Ma, Zelin Chen, Yiming Ouyang, Hu Jin, Shiwu Zhang   +5 more
wiley   +1 more source

Ultrafast RF Spectrum Analyzer Assisted by Optical Short‐Time Fourier Transform

Advanced Physics Research, EarlyView.
We present Recent efforts in an ultrafast RF spectrum analyzer based on the short‐time Fourier transform (STFT) at over 10 MHz frame rate and over 40GHz bandwidth to improve performance and support applications. All these efforts could inspire more innovative applications of temporal imaging modalities in the future.
Liao Chen, Yufan Du, Rongwu Liu, Chi Zhang, Xinliang Zhang   +4 more
wiley   +1 more source

Planar bandpass filter with asymmetric resonators

, 2008
In this Bachelor thesis the microstrip bandpass filter with asymmetric resonators is described. In this work, the proposal, simulation, construction and resulting confrontation parameters realized microstrip bandpass filter in programme Ansoft Designer ...
Cholasta, Lukáš
core   +1 more source

Technology Transfer to Underwater Archaeology: The LAHKE Project at the Submerged Neolithic Site of La Marmotta

Archaeological Prospection, EarlyView.
ABSTRACT This document is a report on the field application of non‐invasive geophysical and robotic prospecting methods at the submerged Neolithic site of La Marmotta (Lake Bracciano, Italy), within the LAHKE (LAke Heritage Knowledge and Exploration) project; the study focuses on the practical validation, adaptation and transfer of existing ...
dell' Erba Ramiro, Cupertino Giacomo, Cipollini Angelo, Luciano Blasi, Quattrucci Luca   +4 more
wiley   +1 more source