Results 231 to 240 of about 146,196 (303)

Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles

Small, EarlyView.
This article highlights a novel, organic solvent‐free lipid nanoparticle (LNP) formulation that avoids cholesterol, thereby reducing hepatic accumulation and immune activation. These BLNPs enable potent, flexible, and scalable gene delivery, supporting personalized medicine and diverse nucleic acid applications.
Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Lucas Gath, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +14 more
wiley   +1 more source

Orthogonal Tri‐Modular Coiled‐Coil Assembly for Programmable Multi‐Cargo Display on Escherichia coli Nissle 1917

Small, EarlyView.
A tri‐specific scaffold cell (TriSC) platform is engineered to enable programmable, reversible, and multiplex surface assembly through orthogonal and spontaneous coiled‐coil interactions. Independent targeting and therapeutic nanobodies are modularly recruited onto bacterial surfaces, allowing tunable combinatorial functionality.
Yong Joon Cho, Gyu‐Jin Lee, Jong‐Ha Park, Sung In Lim   +3 more
wiley   +1 more source

Compostable and Recyclable Baroplastic Triblock Copolymers Enable Low‐Energy Polymer Processing

Small, EarlyView.
Baroplastic Poly(L‐lactide)‐block‐poly(ethylene glycol)‐block‐poly(L‐lactide) triblock copolymers enable ambient‐temperature processing under moderate pressure, reducing energy demand while preserving polymer integrity. The materials show rapid industrial compostability, effective chemical and physical recyclability, and compatibility with heat ...
Chengzhang Xu, Chengwei Yi, Emilia Fulajtar, Anja FRM Ramsperger, Julian Brehm, Christian Laforsch, Holger Schmalz, Sabine Rosenfeldt, Ulrich Mansfeld, Holger Kress, Andreas Möglich, Andreas Greiner, Seema Agarwal   +12 more
wiley   +1 more source

Micro‐Texturized and Ultra‐Soft Dry Electrode for Motion‐Artifact Tolerant and Long‐Term Stable Wearable Electrophysiological Monitoring

Small, EarlyView.
A highly conformal and adhesive dry electrode is developed using a micro‐textured carbon black/PDMS composite. By leveraging spontaneous surface roughness for enhanced mechanical interlocking and integrating a stretchable serpentine interconnector, the device achieves robust skin contact and low impedance.
Sang‐Min Kim, Hee Jeong Jang, Ki‐Hoon Kim, Yeon‐Jeong Hwang, Yu Bin Lee, Joonsoo Jeong, Sunghoon Jung, Eubin Jeong, Dong‐Wook Han, Eui‐Suk Sung, Min‐Ho Seo   +10 more
wiley   +1 more source

Electrically Tunable Tunneling and Spectral Response in WSe2/h‐BN/CdSe/Graphene Heterostructure

Small, EarlyView.
In the WSe2/h‐BN/CdSe quantum dot/graphene heterostructure, the graphene voltage dynamically tunes the tunneling barrier and energy alignment across the h‐BN layer. The bias‐dependent Fermi‐level alignment enhances the tunneling density of states, leading to efficient extraction of photo‐excited electrons from QDs into WSe2 and graphene.
Sang‐Hyeon Lee, Justice Agbeshie Teku, Min‐Hye Jeong, Jae‐Hyeon Ahn, Weon‐Sik Chae, Dohyun Kwak, Jong‐Soo Lee   +6 more
wiley   +1 more source

Portable Radar for Noncontact Heart Rate Monitoring and Estrus Detection in Dairy Cows

IEEJ Transactions on Electrical and Electronic Engineering, EarlyView.
This study introduces a portable radar system for real‐time monitoring of respiratory and heart rates in dairy cows. It uses millimeter‐wave Frequency Modulated Continuous Wave (FMCW) radar to perform noncontact physiological sensing, reducing behavioral disturbance. The radar system's design prioritizes portability, cost‐effectiveness, and robustness,
Yingxiu Li, Ranran Wang, Fuyang Tian, Yudao Li, Zhuolin Wang, Yuxin Yu, Liping Ma, Xin Lu   +7 more
wiley   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

VIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma   +10 more
wiley   +1 more source

A retrospective on the 2025 Atlantic hurricane season

Weather, EarlyView.
The 2025 Atlantic hurricane season was intermittent, with extended quiet periods separated by three clusters of activity. The broad‐scale conditions were often unfavourable for cyclogenesis and common drivers of activity such as La Niña were weak, but well above‐average sea temperatures still supported intense storms.
Charles W. Powell
wiley   +1 more source

Research on Ultra‐Wideband Pulse Current Method for DC Partial Discharge Measurement

High Voltage, EarlyView.
ABSTRACT The conventional pulse current method is commonly used in AC or DC withstand voltage tests with partial discharge (PD) monitoring. Because of its relatively narrow measurement bandwidth, this method tends to ignore critical information in PD waveforms, making it difficult to eliminate pulse‐type interference under DC voltage conditions, where ...
Kaining Hou, Zhaoyang Kang, Dongxin He, Hongshun Liu, Qingquan Li   +4 more
wiley   +1 more source

BirdNET: Automated Detection for Monitoring Critically Endangered Lemurs from the Maromizaha Forest

Integrative Zoology, EarlyView.
In this study, we evaluated the effectiveness of integrating PAM with BirdNET, a convolutional neural network originally developed for avian vocalization detection, to monitor two critically endangered lemurs, Indri indri and Varecia variegata, in Madagascar's Maromizaha rainforest.
Valeria Ferrario, Giacomo Versaci, Giulia Dall'Ava, Chiara De Gregorio, Filippo Carugati, Walter Cristiano, Valeria Torti, Jonah Ratsimbazafy, Cristina Giacoma, Marco Gamba, Daria Valente   +10 more
wiley   +1 more source