Results 151 to 160 of about 1,798,544 (267)

Source characteristics and tectonic impacts on cluster debris flow hazards assessment: Evidence from the Tieba River Basin, NE Qinghai-Tibet Plateau. [PDF]

PLoS One
Xiang L, Shen N, Yang X, Li X, Yang W, Fan W.   +5 more
europepmc   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Research on the deformation mechanisms of red-bed deposits with straight line deposit-bedrock interfaces in Xiangjiaba Reservoir area. [PDF]

Sci Rep
Xiong Y, Dai F, Qi Y, Li S.
europepmc   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Large stocks of permafrost soil organic carbon and nitrogen in Arctic river deltas. [PDF]

Nat Commun
Fuchs M, Sachs T, Jongejans LL, Strauss J, Hugelius G, Frost GV, Jones BM, Kokelj SV, Kutzbach L, Nitze I, Overduin PP, Palmtag J, Ping CL, Pokrovsky OS, Rivkina E, Runge A, Schirrmeister L, Schwamborn G, Siewert MB, Treat C, Veremeeva A, Zubrzycki S, Grosse G.   +22 more
europepmc   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

DEPOSIT RELATIONSHIPS AND BANK PORTFOLIO SELECTION* [PDF]

The Journal of Finance, 1972
openaire   +1 more source

Seismic imagery from volcanoes on the Azores Plateau implies that explosive deep-water eruptions are more common than previously thought. [PDF]

Sci Rep
Hübscher C, Friedrich A, Preine J, Beier C, Hildenbrand A, Nomikou P, Terrinha P, Weiß B.   +7 more
europepmc   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

A dataset of major and trace element composition in sediments of the Loire river basin (France), records covering 1778-2022. [PDF]

Data Brief
Manière L, Grosbois C, Dhivert E, Mondamert L, Labanowski J, Desmet M, Moatar F, Meybeck M.   +7 more
europepmc   +1 more source