Results 221 to 230 of about 3,236,453 (316)

PrOMet: Accurate and Robust Metal‐Binding Site and Type Prediction

Advanced Science, EarlyView.
PrOMet is a two‐stage deep learning framework for jointly predicting metal‐binding sites and ion identities from protein structures. Surface candidate sites are first pruned, followed by refinement of the most probable sites and metal types. This hierarchical strategy enables robust and accurate metal prediction for cryo‐EM and AlphaFold‐derived ...
Gangeun Park, Chaok Seok, Hahnbeom Park
wiley   +1 more source

Structured correction after difficult direct laryngoscopy during prehospital rapid sequence intubation: an eleven-year physician-staffed helicopter emergency medical service registry study. [PDF]

Int J Emerg Med
Soti A, Temesvari P, Hetzman L, Gebei R, Fenyves BG, Varga C.   +5 more
europepmc   +1 more source

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

Advanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh   +12 more
wiley   +1 more source

Genome Sequence of <i>Arthrobacter globiformis</i> Bacteriophage TrixiePhattel. [PDF]

MicroPubl Biol
Hernandez CI, Potter TJ, Mumaw LT.
europepmc   +1 more source

An Expertise Transfer Framework For Autonomous Surgical Assistance

Advanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao, Guangdi Chu, Wei Jiao, Yuchuan Zhong, Hang Yuan, Chengjun Li, Jinhua Li, Shuxin Wang, Bo Guan, Jianchang Zhao, Lizhi Pan, Haitao Niu, Jianmin Li   +12 more
wiley   +1 more source

Establishment of a novel human nervous system tissue bank: University of Debrecen tissue bank-introduction and retrospective data analysis. [PDF]

Cell Tissue Bank
Bencs V, Hortobágyi T, Nagy AC, Kozák M, Méhes G, Oláh L, Csiba L.   +6 more
europepmc   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Predictors of In-Hospital Mortality After Operative Cervical Spinal Cord Injury: A National Trauma Data Bank Analysis From 2021 to 2023. [PDF]

Global Spine J
Ng MK, Mastrokostas LE, Mastrokostas PG, Friedman AJ, Inzerillo S, Jagtiani P, Galina JM, Monas A, Xavier J, Elmenawi K, Seddio AE, Varthi A, Bou Monsef J, Razi AE, Alvarez AP, Kurd MF, Kaye ID, Woods B, Hilibrand AS, Vaccaro AR, Schroeder GD, Kepler CK, Cha TD.   +22 more
europepmc   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Supervised vs. adversarially pre-trained pseudo-label generators for semi-supervised breast cancer patch classification. [PDF]

Front Artif Intell
Zhaksylyk T, Imasheva A, Abdikenov B, Ayanbayev B.   +3 more
europepmc   +1 more source