Results 41 to 50 of about 4,611,339 (304)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Machine learning-based improved method for estimating long-term failure probability with high efficiency of bank slope

Frontiers in Marine Science
Affected by water level and rainfall, the failure probability of bank slope is of great time-dependent characteristics. Combining the random field theory with Monte Carlo simulation strategy to calculate long-term failure probability is a time-consuming ...
Luqi Wang, Luqi Wang, Luqi Wang, Luqi Wang, Tao Wang, Wenyu Yang, Wenyu Yang, Yanfei Kang, Yanfei Kang, Xuanyu Meng   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Study on mechanism and prediction of bank collapse of complex terrace bank slope in southwest China: A case study of front bank collapse in Cizhong

Zhongguo dizhi zaihai yu fangzhi xuebao
Taking the bank collapse in front of the Cizhong resettlement site of the Wunonglong Hydropower Station on the Lancang River as an example, this study analyzed the bank collapse mode and,causative mechanisms, predicted the width and elevation of the bank
Xiaofan AN, Shuangfeng GUO, Hua HU, Guanghong JU, Zhe WANG, Rui ZHU   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Prediction of the Impact of Bank Failure Risk on Micro-Credit in Iran: An Artificial Intelligence Approach [PDF]

International Journal of Management, Accounting and Economics
The aim of this study is to predict the impact of bank default risk on microcredit in Iran. Given the importance of microcredit in creating employment and reducing poverty and inequality, it is necessary to investigate the factors affecting access to ...
Reza Taheri Haftasiabi, Yusef Mohammadzadeh, Ameneh Naderi   +2 more
doaj   +1 more source

IDB News: Vol. 2, no. 6, July 1975

, 1975
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

IDB News: Vol. 1, no. 7, August 1974

, 1974
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source