Results 131 to 140 of about 5,608 (234)

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Behavioural economics intervention to implement a nutrition ranking system in food pantries: Be Well cluster randomised controlled trial protocol. [PDF]

BMJ Public Health
Perez PD, Faulkner KC, Wu Y, Schwartz MB, Caspi C, Burgun R, Ortiz L, Jia J, Cheng J, Chang Y, Levy DE, Thorndike AN.   +11 more
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Rehabilitation needs and challenges in Gaza strip (Palestine) after the ceasefire: A call for coordinated action. [PDF]

J Public Health Res
Jellad A, Chaabeni A, Ben Saad H.
europepmc   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

COMPARATIVE ANALYSIS OF COMMERCIAL BANKS IN POSITIONING FINANCIAL PRODUCTS FOR THE NEEDS OF AGRICULTURAL PRODUCERS IN BULGARIA

Journal of Bio-Based Marketing
This study analyzes financial products offered by commercial banks to agricultural producers in Bulgaria, focusing on farmers’ preferences and banks’ positioning strategies.
Tzvetelina Borisova
doaj  

The WHO pandemic agreement-securing Africa's leadership in a fragmenting global order. [PDF]

BMJ Glob Health
Evaborhene NA, Oga J, Adebisi YA, Udokanma EE, Runyowa N, Kafuko Z, Bandara S, Onyeaghala C.   +7 more
europepmc   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

The Current Landscape and Future Prospects of Vaccine Manufacturing in Africa: Challenges, Innovations, and Opportunities: A Narrative Review. [PDF]

Health Sci Rep
Chandipwisa C, Shimilimo A, Uwishema O, Onyeaka H.   +3 more
europepmc   +1 more source