Results 151 to 160 of about 5,608 (234)

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, EarlyView.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Effects of Interventions to Improve Access to Financial Services for Micro, Small, and Medium-Sized Enterprises in Low- and Middle-Income Countries: An Evidence and Gap Map. [PDF]

Campbell Syst Rev
Dela Cruz NAO, Villanueva ACB, Tolin L, Disse S, Lensink R, White H.   +5 more
europepmc   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Financing pandemic prevention, preparedness and response: lessons learned and perspectives for future. [PDF]

Global Health
Ndembi N, Dereje N, Nonvignon J, Aragaw M, Raji T, Fallah MP, Abdulaziz M, Djoudalbaye B, Aluso A, Boum Ii Y, Mwaba G, Shisana O, Ngongo N, Kaseya J.   +13 more
europepmc   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Using perception as a strategy: Camouflage, surprise, and the moment of shock related to perception. [PDF]

Iperception
Carbon CC, Dreyer B, Speck M.
europepmc   +1 more source

BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression

Advanced Science, EarlyView.
BZW1 attenuates ferroptosis by competitively binding NCOA4 and suppress ferrtinophagy‐mediated iron release. The depletion of BZW1 triggers lipid peroxidation through iron homeostasis. Extracellularly, BZW1 attenuates immunogenic cell death and reinvigorates cytotoxic T‐cell responses.
Linyao Zhao, Yue Peng, Qing Liang, Shi Liu, Yang Li, Lei Ma, Menghan Hu, Sujuan Zheng, Zhihua Liu, Shugeng Gao   +9 more
wiley   +1 more source

The role of government in helping SMEs to access finance: An evolutionary game modeling and simulation approach. [PDF]

PLoS One
Mei Z, Zhang J, Zhou Q.
europepmc   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, EarlyView.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source

No time to wait: resilience as a cornerstone for primary health care across Latin America and the Caribbean, a World Bank-PAHO Lancet Regional Health Americas Commission. [PDF]

Lancet Reg Health Am
Herrera CA, Bascolo E, Villar-Uribe M, Houghton N, Bennett S, Castro MC, Massuda A, Bauhoff S, Cunningham Kain MK, Figueroa JP, Flores W, Gaitán-Rossi P, Garcia Elorrio E, Giovanella L, Guanais F, Haggerty J, Peña SH, Luna D, Macinko J, Molina H, Pinto D, Rathe M, Madrigal MDRS, Tasca R, Vance Mafla CI, Mansilla C, Haldane V, Abanto A, Alfonso YN, Aranda LE, Gonzalez-Samano M, Jimenez CZ.   +31 more
europepmc   +1 more source