Results 181 to 190 of about 920,134 (306)

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

Phylogenomic Barcoding of Soil Seed Bank-Persistent and Wind-Dispersed Non-Native Plant Species in South Georgia. [PDF]

Mol Ecol Resour
Viruel J, Sweeney CJ, Day R, White K, Dawson W, Myer B, Floyd K, Corcoran M, Kelting C, Poncet S, Forest F, Clubbe C, Newton RJ.   +12 more
europepmc   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Bridging the Structural Gap: A Methodological Review of Cryo-Electron Microscopy for Underrepresented Viruses. [PDF]

Viruses
Park YH, Jung HS, Moon S, Song C.
europepmc   +1 more source

Real‐Time In Vivo Visualization of Tumor‐Associated Macrophage Reprogramming Using a Nitric Oxide‐Activatable NIR‐II Nanoinducer

Advanced Science, EarlyView.
Reprogramming tumor‐associated macrophages is a promising therapeutic strategy for solid tumors. Here, a nitric oxide (NO)‐activatable NIR‐II fluorescence/photoacoustic nanoinducer (I/E@M2pep) that simultaneously facilitates and visualizes the repolarization of TAMs to an M1‐like phenotype is reported, thereby enhancing anti‐tumor efficacy through M1 ...
Qian Chen, Meng Li, Tuanwei Li, Chen Yang, Xiaohu Yang, Hongchao Yang, Yejun Zhang, Chunyan Li, Qiangbin Wang   +8 more
wiley   +1 more source

TSMS-SAM2: Multi-scale Temporal Sampling Augmentation and Memory-Splitting Pruning for Promptable Video Object Segmentation and Tracking in Surgical Scenarios. [PDF]

Mach Learn Health
Xu G, Shao HC, Zhang Y.
europepmc   +1 more source

scResponse: A Rank‐Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single‐Cell Data

Advanced Science, EarlyView.
Although the tumor microenvironment is known to shape immunotherapy response, its key determinants remain elusive, underscoring the critical need for single‐cell resolution analytical frameworks. We present scResponse, an efficient algorithm to quantify single‐cell responses to immunotherapy. By capturing diverse cellular subtypes and states associated
Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao   +21 more
wiley   +1 more source

Cost-effective drone monitoring and evaluating toolkits for stream habitat health: development and application. [PDF]

Environ Monit Assess
Wang W, Lu B, Wu CH.
europepmc   +1 more source

Synergistic Pyro‐Phototronics and Structural Anisotropy in CsAg2I3/GaN Heterostructures for High‐Performance Polarization‐Sensitive UV Photodetectors

Advanced Science, EarlyView.
The development of polarization‐sensitive ultraviolet photodetectors is limited by poor heterojunction quality and low polarization sensitivity. This study integrates synthesized CsAg2I3 single crystals with intrinsic non‐centrosymmetry into van der Waals heterojunction devices, demonstrating pronounced pyro‐phototronic effect.
Yalin Zhai, Siqi Wang, Peng Guo, Songling Feng, Peng Wan, Jilong Tang, Caixia Kan, Hui Li, Daning Shi, Mingming Jiang   +9 more
wiley   +1 more source

Structural insights into the gating mechanism of the fission yeast phosphate exporter SpXpr1. [PDF]

Cell Discov
Yang H, Wang Y, Yue C, Li X, Wang Y, Yu Y, Shen H.   +6 more
europepmc   +1 more source