Results 181 to 190 of about 12,019 (296)
Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis
Advanced Science, EarlyView.Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu +13 more
wiley +1 more source
Shaped by crisis, rooted in community: Lessons from Lebanon's palliative care model. [PDF]
Palliat Care Soc PractEl Khoury J +4 more
europepmc +1 more source
THE SOUNDNESS OF THE BANKING SYSTEM DURING THE GLOBAL FINANCIAL CRISIS
, 2014 Ioana-Iuliana Tomuleasa
openalex +1 more source
The Failure of Criminal Law to Control the Use of Off Balance Sheet Finance During the Banking Crisis [PDF]
, 2015 Stephen Copp, Alison Cronin
openalex
Advanced Science, EarlyView.This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen +7 more
wiley +1 more source
An overview of CBDCs and their potential role in the green economy. [PDF]
Open Res EurKontzinos C +5 more
europepmc +1 more source
Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition
Advanced Science, EarlyView.Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han +9 more
wiley +1 more source