Results 111 to 120 of about 241,185 (309)
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer
Advanced Science, EarlyView.This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu +10 more
wiley +1 more source
Improving regulations and supervision of pension funds : are there lessons from the Banking Sector? [PDF]
The main objective of this paper is to review the regulatory framework for pension funds, and examine whether there is scope for improvements in pension regulation, particularly in light of regulatory and supervisory developments in the banking industry.
Gutierrez, Joaquin +2 more
core
Advanced Science, EarlyView.The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo +14 more
wiley +1 more source
The Role of External Auditors and International Accounting Bodies in Financial Regulation and Supervision. [PDF]
The emergence of powerful financial conglomerates operating at a global level has led to unified supervision of financial services in the UK and Germany.
Ojo, Marianne
core +1 more source
Advanced Science, EarlyView.In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu +18 more
wiley +1 more source
SYSTEMIC RISK AND MACROPRUDENTIAL POLICY IN THE BANKING SECTOR [PDF]
Annals of the University of Petrosani: Economics, 2018 The purpose of this paper is to provide a perspective on the crucial importance of financial stability and the significant role of prudential regulations and banking supervision to ensure the solvency and viability of the banking system.
IMOLA DRIGĂ
doaj
المجلة الدولية للأداء الاقتصادي, 2023 هدفت الدراسة إلى البحث في أثر تطبيق مبادئ الحوكمة المصرفية في زيادة فعالية وكفاءة الأداء المصرفي، وتوصلت الدراسة إلى وجود علاقة طردية بين تبني مبادئ الحوكمة المصرفية الصادرة عن لجنة ازل 3 للرقابة والإشراف والتحسين المستمر لأداء البنوك، وأوصت الدراسة ...
Nabila LAKHAL, Loubna ZAYED KAYOUCHE
doaj
Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment
Advanced Science, EarlyView.Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun +5 more
wiley +1 more source