Results 151 to 160 of about 241,185 (309)
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
Some thoughts on the evolution of the banking system and the process of financial intermediation [PDF]
The author discusses three areas she considers important in the evolution of the financial services industry: consolidation and the economies gained from it, governance issues that emerge as the structure of the banking industry changes, and the decline ...
Loretta J. Mester
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Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source
Market and risk management innovations: implications for safe and sound banking [PDF]
This commentary reviews three of the major innovations suggested in Benston et al. (1986): movement toward greater risk-sensitive approaches, an enhanced role for market discipline and disclosure, and earlier intervention for troubled banks.
Eric S. Rosengren
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Advanced Science, EarlyView.PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang +17 more
wiley +1 more source
Central Bank or Single Financial Supervision Authority: The Romanian Case [PDF]
The process of regulation and supervision of the financial system represents a pillar for the financial stability. A recent trend in the institutional framework for financial supervision is the creation of a Single Supervision Authority for the ...
Albulescu, Claudiu Tiberiu
core +1 more source
Advanced Science, EarlyView.WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang +6 more
wiley +1 more source
Модернизация, инновация, развитие, 2015 The article is devoted to comprehensive analysis of the concept of professional motivated judgment applied regulator (Bank of Russia) in respect of a credit institution.
E. E. Frolova, E. V. Karmadonova
doaj
Opening remarks to "Beyond Pillar 3 in International Banking Regulation: Disclosure and Market Discipline of Financial Firms," a Conference Cosponsored by the Federal Reserve Bank of New York and the Jerome A.
Jamie B. Stewart, Jr.
core