Results 231 to 240 of about 17,621,601 (259)

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

From human-like AI to user adoption: the role of trust, attitude, and social influence in shaping behavioral intention. [PDF]

Front Artif Intell
Helen H, Arief M, Maulana AE, Heriyati P.   +3 more
europepmc   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Establishing food-safe cell lines and banks for cultivated meat: current status and future directions. [PDF]

Poult Sci
Mia N, Hashem MA, Rahman MM, Ahamed Z.
europepmc   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

Partnership models in eye banking - Impact and relevance in Indian context. [PDF]

Indian J Ophthalmol
Gupta N, Chaurasia S.
europepmc   +1 more source

Market competition in banking and asset-liability maturity mismatch of non-financial firms: Evidence from Vietnam. [PDF]

PLoS One
Phan TMH, Huynh J.
europepmc   +1 more source

Improving resilience in human milk banking: workshop proceedings, 11th November, London UK. [PDF]

BMC Proc
Shenker N, Hatia A, Griffin S, Chandler-Maini G, Bailie L, Barnett D, Savage E, D'Souza A, Dowling C, Gane T, Stroud S, Wood A, Holder G, Crawley H, Sibson V, Gray H, Fallon N, Brackley M, Hinds H, Turner H, Hogan M, Kemp D, Kennedy A, Kerac M, Meeajan R, Mistry H, O'Sullivan L, Patton C, Staff M, Zuber L, Thomson M, Shariff A, Psaila V, Green A, Watt J, Partridge G, Crombie T, Webster F, Cameron S, Cheema S, Brown A, Weaver G, Easthope L.   +42 more
europepmc   +1 more source

Health service disruptions under economic sanctions: evidence from Iran. [PDF]

Int J Equity Health
Malgard S, Afshari M, Ahmadi SAY, Doshmangir L, Asadi-Lari M.   +4 more
europepmc   +1 more source

Sperm banking in testicular cancer survivors Low utilization, high costs, and patient-reported barriers from a Canadian cohort. [PDF]

Can Urol Assoc J
Lu S, Ko Y, Fathy M, Patel P.
europepmc   +1 more source