Results 101 to 110 of about 399,821 (301)

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

open access: yesAdvanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li   +19 more
wiley   +1 more source

On the determinants of banking efficiency in four new European Union Member States: the impact of structural reforms [PDF]

open access: yes
We employ the stochastic frontier methodology and estimate alternative profit efficiency in the banking industry of four new European Union Member States, namely the Czech Republic, Hungary, Poland and the Slovak Republic, over the period 1999-2003.
Koutsomanoli-Filippaki, Anastasia   +2 more
core   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik   +13 more
wiley   +1 more source

Banking systems of EU Member States

open access: yesПутеводитель предпринимателя, 2020
The article discussed the current state of the banking system of the countries- EC members and problems they faced. Marked difficulties in the activities of certain leading banks of the eurozone and the reasons for the creation of the Banking Union.
E. A. Barinov
doaj  

Shadow banking, Banking Union and Capital Markets Union [PDF]

open access: yes, 2014
This paper analyses the development of shadow banking and considers the challenges it poses for regulators and supervisors vis-à-vis latest developments regarding i) the Banking Union, which led to the Single Supervisory Mechanism that became operational in November 2014, and ii) the Capital Markets Union that is one of the most important projects of ...
openaire  

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

open access: yesAdvanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen   +22 more
wiley   +1 more source

The political economy of the European banking union

open access: yesKöz-gazdaság, 2020
Banking union has become the most spectacular result of the reform of European economic governance. The article demonstrates that the institutions and mechanisms of the European banking union can be interpreted as the outcome of a bargaining process ...
István Benczes
doaj  

Bank resolution and recovery in the EU: enhancing banking union? [PDF]

open access: yes, 2018
The article analyses some of the legal and economic policy issues concerning proposals to establish a European Banking Union. It discusses the role of the European Central Bank as a bank supervisor and the creation of the Single Supervisory Mechanism ...
Alexander, Kern
core  

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider   +20 more
wiley   +1 more source

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