Results 101 to 110 of about 5,215,204 (290)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

State of Connecticut Department of Banking

open access: yes, 2007
Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed Nov. 19, 2010).; At head of title: State of Connecticut.; Harvested from the web on 1/5/11Official website of the Connecticut Department of Banking.

core   +3 more sources

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

open access: yesAdvanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka   +10 more
wiley   +1 more source

What kind of European Banking Union? Bruegel Policy Contribution 2012/12, June 25, 2012 [PDF]

open access: yes, 2012
This paper discusses the creation of a European Banking Union. First, we discuss questions of design. We highlight seven fundamental choices that decision makers will need to make: Which EU countries should participate in the banking union?
Sapir, André   +3 more
core  

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang   +14 more
wiley   +1 more source

Banking systems of EU Member States

open access: yesПутеводитель предпринимателя, 2020
The article discussed the current state of the banking system of the countries- EC members and problems they faced. Marked difficulties in the activities of certain leading banks of the eurozone and the reasons for the creation of the Banking Union.
E. A. Barinov
doaj  

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

open access: yesAdvanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang   +16 more
wiley   +1 more source

The political economy of the European banking union

open access: yesKöz-gazdaság, 2020
Banking union has become the most spectacular result of the reform of European economic governance. The article demonstrates that the institutions and mechanisms of the European banking union can be interpreted as the outcome of a bargaining process ...
István Benczes
doaj  

CONSIDERATIONS REGARDING THE CREATION OF A EUROPEAN BANKING UNION – A KEY ELEMENT IN REINFORCING THE BANKING SYSTEM [PDF]

open access: yesChallenges of the Knowledge Society, 2015
The idea of setting up a European Banking Union, an essential element in the reinforcement of the Economic and Monetary Union (EMU), has become a concrete project and it has been outlined as such after the financial crisis started in 2007. The setting up
Mădălina Antoaneta RĂDOI   +1 more
doaj  

Banking Union: are the EMU design mistakes being repeated? European Policy Brief No. 12, October 2012 [PDF]

open access: yes, 2012
This Policy Brief pleads for an unambiguous commitment by eurozone leaders to establishing a Banking Union that is based on all three of its pillars: common supervision, a single bank resolution authority and a joint deposit insurance.
Verhelst, Stijn
core  

Home - About - Disclaimer - Privacy