Results 191 to 200 of about 2,272,414 (343)

Continuing industrial emissions are delaying the recovery of the stratospheric ozone layer. [PDF]

open access: yesNat Commun
Reimann S   +13 more
europepmc   +1 more source

Seabed mapping for selecting cold-water coral protection areas on Hatton Bank, Northeast Atlantic [PDF]

open access: bronze, 2009
P. Durán-Muñoz   +10 more
openalex   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

open access: yesAdvanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li   +23 more
wiley   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

open access: yesAdvanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen   +14 more
wiley   +1 more source

An Unusually Deep Corallimorph Barren on a Remote Coral Reef in the South-Central Red Sea. [PDF]

open access: yesEcol Evol
Rich WA   +7 more
europepmc   +1 more source

Sperm cryopreservation in the human sperm bank: 11-year results of the Chinese mainland sperm banking network

open access: gold, 2022
Xiao Liu   +25 more
openalex   +1 more source

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

open access: yesAdvanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber   +12 more
wiley   +1 more source

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