Results 241 to 250 of about 621,805 (313)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Stoneflies (Insecta, Plecoptera) of the Midwest, USA: species checklist derived from nearly 170 Years of collection records. [PDF]

Biodivers Data J
Hogan PN, DeWalt RE, Grubbs SA.
europepmc   +1 more source

Fenced enclosure and increased rainfall facilitate recovery of degraded desert steppe by restructuring soil seed bank dynamics. [PDF]

BMC Plant Biol
Chen H, Fan G, Baskin CC, Baskin JM, Cui Q, Liu H, Huang Z.   +6 more
europepmc   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

General healthcare preferences for people aged 50 and over in England: English longitudinal study of ageing. [PDF]

PLoS One
Steel N, Zaninotto P, Enwo OO, Banks J.
europepmc   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Mobilizing the banking sector for universal health coverage: a new frontier for public-private partnerships. [PDF]

Front Health Serv
Obi CG, Uzor FU.
europepmc   +1 more source

Financial development and economic growth in Sub-Saharan Africa using system GMM analysis. [PDF]

PLoS One
Ergano TY, Rao SP.
europepmc   +1 more source

Supporting the Synergy Between School Meal Programs and Food Banks to Combat Food Insecurity Among Children: A Bayesian Mindsponge Framework Analysis. [PDF]

Health Sci Rep
Sari NPWP, Katiyatiya CLF, Mazenda A, Chakanya C, Nguyen MH, Vuong QH.   +5 more
europepmc   +1 more source

Crimean-Congo haemorrhagic fever and critical care readiness amid Afghanistan's returnee crisis. [PDF]

Crit Care
Takal H.
europepmc   +1 more source