Results 51 to 60 of about 548,941 (325)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Liability of construction participants for delays

open access: yesBusiness, Management and Education, 2011
Date of completion is usually set forth in construction contract agreements as one of the most important provisions. Also, it is the provision, which is often violated and the violation results in a dispute between the parties to the agreement.
Sigitas Mitkus, Aurelija Sekonaitė
doaj   +1 more source

Habitat mapping and conservation threats to river dolphin in Karnali River of Nepal [PDF]

open access: yes, 2009
This study was carried out in the Karnali River of Nepal with the aims of preparing habitat map of dolphins in the Karnali River and assessing conservation threats to dolphin at the local level. The habitat map of the dolphin was prepared on the basis of

core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Interpreting Bar Charts: Effects of 3D Depth Cues on Human Gaze and User Understanding

open access: yesDigital
Three-dimensional information visualizations are widely used in various fields for their aesthetic appeal. However, using them can sometimes lead to occlusion and distortion, which raises questions about when and why to use them.
Ana Svalina   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Economic design of X-bar control chart using simulated annealing [PDF]

open access: yes, 2011
Control charts are widely used in industry for monitoring and controlling manufacturing processes. They should be designed economically in order to achieve minimum quality control costs.
Darun , Prasath.L
core  

Kinematics of the Galactic Globular Cluster System: New Radial Velocities for Clusters in the Direction of the Inner Galaxy [PDF]

open access: yes, 1999
HIRES on the Keck I telescope has been used to measure the first radial velocities for stars belonging to eleven, heavily-reddened globular clusters in the direction of the inner Galaxy.
Alcaino G.   +23 more
core   +2 more sources

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