Results 151 to 160 of about 252,506 (348)
Flying under the radar: DNA barcoding ray wings in Greece detects protected species and umbrella labelling terms
, 2021 Giagkazoglou, Zoe, Griffiths, Andrew M., Imsiridou, Anastasia, Chatzispyrou, Archontia, Touloumis, Konstantinos, Hebb, Jake L., Mylona, Dimitra, Malamidou, Anna K., Apostolidi, Evangelia D,, Batjakas, Ioannis E., Gubili, Chrysoula +10 moreopenalex +1 more sourceActivation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury
Advanced Science, EarlyView.In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang +13 morewiley +1 more sourceProton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells
Advanced Science, EarlyView.This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha +11 morewiley +1 more sourceMyeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis
Advanced Science, EarlyView.Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin +6 morewiley +1 more sourceDesign of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment
Advanced Science, EarlyView.ABSTRACT
Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang +12 morewiley +1 more sourcePeer Review #1 of "Global gap-analysis of amphipod barcode library (v0.1)"
, 2021 Anna Maria, Jażdżewska Corresp, Anne Helene S. Tandberg, Tammy Horton, Saskia Brix, Anna М. Jażdżewska, T Arfianti, S Wilson, M Costello, E Aylagas, A Borja, I Muxika, N Rodrguez-Ezpeleta, J Barnard, G Karaman, M Bauz-Ribot, D Jaume, J Forns, C Juan, J Pons, J Beermann, A Hall-Mullen, C Havermans, J Coolen, R Crooijmans, B Dibbits, C Held, A Desiderato, Bij De Vaate, A Jazdzewski, K Ketelaars, Ham Gollasch, S Van Der Velde, G, A Brandt, A Brandt, I Alalykina, S Brix, N Brenke, M Baewicz, O Golovan, N Johannsen, A Hrinko, A Jadewska, K Jeskulke, G Kamenev, A Lavrenteva, M Malyutina, T Riehl, L Lins, A Brandt, De Broyer, C, De Mesel, I Ellingsen, K Gooday, A Hilbig, B Linse, K Thomson, M Tyler, P, A Brante, G Guzmn-Rendn, E Barra, M Guillemin, I Vera-Escalona, C Hernndez, S Brix, A-N Lrz, A Jadewska, L Hughes, A Tandberg, K Pabis, B Stransky, T Krapp-Schickel, J-C Sorbe, E Hendrycks, Wjm Vader, I Frutos, T Horton, K Jadewski, R Peart, J Beermann, Coleman Co, L Buhl-Mortensen, L Corbari, C Havermans, R Tato, Jimenez Campean, A, S Brix, K Osborn, S Kaiser, S Truskey, S Schnurr, N Brenke, M Malyutina, Martinez Arbizu, P, M Bundschuh +99 moreopenalex +2 more sourcesA Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Advanced Science, EarlyView.This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang +16 morewiley +1 more sourceIntegration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation
Advanced Science, EarlyView.This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun +9 morewiley +1 more source