Results 41 to 50 of about 22,901 (274)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Beyond Field Effect: Analysis of Shrunken Centroids in Normal Esophageal Epithelia Detects Concomitant Esophageal Adenocarcinoma

Bioinformatics and Biology Insights, 2007
Background and Aims Because of the extremely low neoplastic progression rate in Barrett's esophagus, it is difficult to diagnose patients with concomitant adenocarcinoma early in their disease course.
Florin M. Selaru, Suna Wang, Jing Yin, Karsten Schulmann, Yan Xu, Yuriko Mori, Alexandru V. Olaru, Fumiaki Sato, James P. Hamilton, John M. Abraham, Paul Schneider, Bruce D. Greenwald, Jan Brabender, Stephen J. Meltzer M.D.   +13 more
doaj   +2 more sources

A bidirectional Mendelian randomization study integrating genome-wide association studies, expression quantitative trait locus, and methylation quantitative trait locus data revealed causal relationship between heavy cigarette dependence and Barrett’s esophagus

SAGE Open Medicine
Background: The association between smoking dependence and the risk of developing Barrett’s esophagus remains unclear. This study aimed to investigate whether a causal relationship exists between smoking dependence and Barrett’s esophagus, using ...
Zhou An, Meichun Zeng, Xianhua Wang
doaj   +1 more source

The Hybrid-APC in the endoscopic treatment of Barrett's esophagus

Archivo Médico de Camagüey, 2021
Background: due to the risk of unsatisfactory evolution of patients with Barrett's esophagus (EB) towards esophageal adenocarcinoma, it is necessary to apply safe and effective techniques that prevent the outcome towards esophageal malignant lesions. The
Mildred Cecilia Armenteros-Torres, Raúl Antonio Brizuela-Quintanilla, Elizabeth Montes-de-Oca-Megias, Vivianne María Anido-Escobar, Aris Nubia Betancourt-Navarro   +4 more
doaj  

Length of Barrett’s segment predicts failure of eradication in radiofrequency ablation for Barrett’s esophagus: a retrospective cohort study

BMC Gastroenterology, 2018
Background We aim to investigate factors that may contribute to failure of eradication of dysplastic Barrett’s Esophagus among patients undergoing radiofrequency ablation treatment.
Tyler Luckett, Chaitanya Allamneni, Kevin Cowley, John Eick, Allison Gullick, Shajan Peter   +5 more
doaj   +1 more source

HOXA13 in etiology and oncogenic potential of Barrett’s esophagus

Nature Communications, 2021
Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the ...
Vincent T. Janmaat, Kateryna Nesteruk, Manon C. W. Spaander, Auke P. Verhaar, Bingting Yu, Rodrigo A. Silva, Wayne A. Phillips, Marcin Magierowski, Anouk van de Winkel, H. Scott Stadler, Tatiana Sandoval-Guzmán, Luc J. W. van der Laan, Ernst J. Kuipers, Ron Smits, Marco J. Bruno, Gwenny M. Fuhler, Nicholas J. Clemons, Maikel P. Peppelenbosch   +17 more
doaj   +1 more source

Sex steroid hormones in relation to Barrett’s esophagus: An analysis of the FINBAR Study [PDF]

, 2017
Previously we observed strong positive associations between circulating concentrations of free testosterone and free dihydrotestosterone (DHT) in relation to Barrett’s esophagus in a US male military population.
Abnet, Christian C, Anderson, Lesley A, carson, Patrick, Cook, M. B., Dawsey, Sanford M, Drahos, Jennifer, Falk, Roni T, Guillemette, Chantal, Hyland, Paula L, Murray, Liam J, Pfeiffer, Ruth, Taylor, Philip R, Wood, Sharon   +12 more
core   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

The Prevalence and Risk Factors of GERD Among Indonesian Medical Doctors [PDF]

, 2016
Background: Based on our knowledge, the study of gastrointestinal reflux disease (GERD) among certain profession has never been conducted. The aim of this study is to determine the prevalence and risk factors of GERD among Indonesian doctors.
Hapsari, P. F. (Puspita), Makmun, D. (Dadang), Syam, A. F. (Ari)   +2 more
core   +3 more sources

Barrett's esophagus in childhood [PDF]

Gastroenterology, 1984
This study describes the clinical, radiologic, esophageal function test, endoscopic, and histologic findings of Barrett's esophagus in 11 children aged 6-14 yr. All had long-standing symptoms of gastroesophageal reflux, which had begun in the first year of life in 10 of the 11.
E, Hassall, W M, Weinstein, M E, Ament
openaire   +2 more sources