Results 121 to 130 of about 1,221,418 (303)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Benefits of Improving Urban Park Playground Facilities through Inclusive Design Concept Using Computer Software

Engineering Proceedings
For inclusive design, we conducted the Taichung Melody Project to enhance the urban park’s children’s playground in terms of inclusivity and user-friendliness.
Jung-Hua Wu, Sheng-Jung Ou, Wei-Chieh Yeh, Huang-Liang Lee   +3 more
doaj   +1 more source

Research on Barrier-free Design of House Environment [PDF]

Proceedings of the 2018 International Conference on Advances in Social Sciences and Sustainable Development (ASSSD 2018), 2018
Houping Deng, Hui Wang
openaire   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Research on Design Optimization of Barrier-Free Public Facilities

Highlights in Science, Engineering and Technology
With the change in the development of civilization, China has paid more and more attention to the people-oriented concept, and the degree of care for special groups such as the disabled has gradually increased. However, due to the increase of the population base and the expansion of urbanization areas, the demand for infrastructure is expanding, and ...
openaire   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Enhancing piezoelectric coefficient and thermal stability in lead-free piezoceramics: insights at the atomic-scale

Nature Communications
Given the highly temperature-sensitive nature of the polymorphic phase boundaries, attaining excellent piezoelectric coefficient with superior temperature stability in lead-free piezoceramics via direct compositional design remains a formidable challenge.
Jinzhu Zou, Miao Song, Xuefan Zhou, Wenchao Chi, Tongxin Wei, Kechao Zhou, Dou Zhang, Shujun Zhang   +7 more
doaj   +1 more source

Barrier function-based adaptive synergetic control with state constraints for manipulator with uncertainty and input saturation

Ain Shams Engineering Journal
This study proposes a barrier function-based adaptive nonsingular terminal synergetic control to mitigate chattering and uncertainty in a nonlinear system with hard state constraints and actuator saturation.
Muhammad Auzan, Yong-Lin Kuo
doaj   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source