Results 101 to 110 of about 1,327,323 (292)
Large transconductance oscillations in a single-well vertical Aharonov-Bohm interferometer
, 2000 Aharonov-Bohm (AB) interference is reported for the first time in the conductance of a vertical nanostructure based on a single GaAs/AlGaAs quantum well (QW).
C. J. B. Ford +15 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Great Barrier Reef Tourism Climate Change Action Strategy 2009-2012: Abridged [PDF]
, 2009 Climate change represents one of the single biggest challenges facing the globe today. For the Great Barrier Reef, climate change is a significant issue as the future health of the Great Barrier Reef and the sustainability of its tourism industry are ...
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Great Barrier Reef Marine Park Authority Science Strategy and Information Needs 2014-2019 [PDF]
, 2014 The Science Strategy and Information Needs 2014–2019 sets out the future scientific information needs of the agency. It aims to ensure that science activities are relevant, targeted to address critical management issues and their outcomes are easily ...
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Implementation of guidelines in clinical practice; barriers and strategies
Current Opinion in AnaesthesiologyPurpose of review Published clinical practice guidelines frequently have difficulties for implementation of the recommendations and adherence in daily clinical practice. The present review summarizes the current knowledge on the barriers encountered when implementing clinical practice guideline and the strategies proposed to ...
De Hert, Stefan +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Draft Aboriginal and Torres Strait Islander heritage strategy for the Great Barrier Reef Marine Park [PDF]
, 2018 [Extract] The Draft Aboriginal and Torres Strait Islander heritage strategy for the Great Barrier Reef sets out a vision, guiding principles, objectives, actions and anticipated outcomes for how the Great Barrier Reef Marine Park Authority will work with
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source