Results 141 to 150 of about 31,542,963 (350)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

PENGARUH PENGGUNAAN BIOSUPLEMEN MENGANDUNG BAKTERI PROBIOTIK SELULOLITIK ASAL RAYAP (Termites sp.) TERHADAP PRODUKTIVITAS ITIK BALI JANTAN

Majalah Ilmiah Peternakan, 2018
The research aims at analyzing the effect use of probiotic cellulolytic biosuplement termite (Termites sp.) to the productivity of male bali ducks. Bacteria isolates used were first and second preeminent probiotic cellulolytic bacteria isolated derived ...
LAKSMI DEWI M. P., N. S. SUTAMA, G. A. M KRISTINA DEWI   +2 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

Journal of Cell Biology, 2011
Eight proteins, defects in which are associated with Meckel-Gruber syndrome and nephronophthisis ciliopathies, work together as two functional modules at the transition zone to establish basal body/transition zone connections with the membrane and ...
Corey L. Williams, Chunmei Li, K. Kida, P. N. Inglis, Swetha Mohan, Lucie Semenec, Nathan J. Bialas, Rachel M. Stupay, Nansheng Chen, O. Blacque, B. Yoder, M. Leroux   +11 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Nascent flagellar basal bodies are immobilized by rod assembly in Bacillus subtilis

mBio
Flagella are complex, trans-envelope nanomachines that localize in species-specific patterns on the cell surface. Here, we study the localization dynamics of the earliest stage of basal body formation in Bacillus subtilis using a fluorescent fusion to ...
Caroline M. Dunn, Daniel J. Foust, Yongqiang Gao, Julie S. Biteen, Sidney L. Shaw, Daniel B. Kearns   +5 more
doaj   +1 more source

The metabolic cost of physical activity in mice using a physiology-based model of energy expenditure

Molecular Metabolism, 2023
Objective: Physical activity is a major component of total energy expenditure (TEE) that exhibits extreme variability in mice. Our objective was to construct a general, physiology-based model of TEE to accurately quantify the energy cost of physical ...
Vojtěch Škop, Juen Guo, Naili Liu, Cuiying Xiao, Kevin D. Hall, Oksana Gavrilova, Marc L. Reitman   +6 more
doaj  

Studies of the basal metabolism and its relation to the body surface in obesity, myxedema, and pituitary disease [PDF]

, 1914
J. H. Means
openalex   +1 more source

Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle [PDF]

, 2019
Placental insufficiency causes intrauterine growth restriction (IUGR) and disturbances in glucose homeostasis with associated β adrenergic receptor (ADRβ) desensitization.
Allen, Ronald E., Anderson, Miranda J., Antolic, Andrew T., Camacho, Leticia E., Davis, Melissa A., Goyal, Ravi, Hay, William W., Jr, Kelly, Amy C., Limesand, Sean W., Papas, Klearchos K., Steyn, Leah V., Yates, Dustin T.   +11 more
core   +1 more source

Drosophila chibby is required for basal body formation and ciliogenesis but not for Wg signaling

Journal of Cell Biology, 2012
In contrast to vertebrate CBY, which functions in WNT signaling, Drosophila CBY is essential for normal basal body structure and function but dispensable for Wg signaling.
Camille Enjolras, Joëlle Thomas, Brigitte Chhin, Elisabeth Cortier, Jean-Luc Duteyrat, F. Soulavie, Maurice J. Kernan, A. Laurençon, B. Durand   +8 more
semanticscholar   +1 more source