Results 81 to 90 of about 37,731,658 (401)

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Gorlin syndrome in a patient with skin type VI [PDF]

open access: yes, 2019
Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant disorder that is characterized by multiple basal cell carcinomas developing at a young age, keratocystic odontogenic tumors of the jaw, palmar or plantar ...
Anderson, Kathryn L   +3 more
core  

Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. [PDF]

open access: yes, 2017
Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology.
Chen, Yiling   +4 more
core   +2 more sources

Avasimibe Alleviates Disruption of the Airway Epithelial Barrier by Suppressing the Wnt/β-Catenin Signaling Pathway

open access: yesFrontiers in Pharmacology, 2022
Avasimibe (Ava) is an acetyl-CoA acetyltransferase 1 (ACAT1) specific inhibitor and an established medicine for atherosclerosis, owing to its excellent and safe anti-inflammation effects in humans.
Zicong Zhou   +7 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

The developmental cell biology of Trypanosoma brucei [PDF]

open access: yes, 2005
Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R
core   +1 more source

Topical photodynamic therapy [PDF]

open access: yesArchive of Oncology, 2006
Topical photodynamic therapy is a therapeutic modality in development, thus arises grate interest among dermatologists worldwide. It is an effective therapy for actinic keratosis, superficial BCC and Bowenos disease.
Poljački Mirjana   +5 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Basal cell carcinoma: 10-year experience with electrochemotherapy [PDF]

open access: yes, 2017
BACKGROUND: Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy.
Alaibac, MAURO SALVATORE ALESSANDRO   +6 more
core   +2 more sources

Carcinoma basocelular da pálpebra: fatores relacionados com a recidiva tumoral Basal cell carcinoma of the eyelid: factors related to recurrence

open access: yesAnais Brasileiros de Dermatologia, 2004
FUNDAMENTOS: O carcinoma basocelular (CBC) palpebral é o tumor maligno mais freqüente das pálpebras, sendo possível observar casos em que existe recidiva após a exérese tumoral.
Luciana Akemi Ishi   +4 more
doaj   +1 more source

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