Results 191 to 200 of about 233,135 (260)

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

Deep learning analysis of reflectance confocal microscopy for basal cell carcinoma diagnosis. [PDF]

JAAD Int
O'Hagan R, Acciardi A, Rodríguez MT, Mehta J, Ciardo S, Alma A, Navrazhina K, Gulati N, Farabi Atak SB, Farnetani F.   +9 more
europepmc   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

A Phase II Trial of Perioperative Oral Itraconazole for the Management of Low-Risk Basal Cell Carcinoma. [PDF]

Exp Dermatol
Pereira RP, Sirena DH, de Azevedo SJ, da Silva MMF, da Luz Andrade MM, Ferreira CF, Heinen TE, Bakos RM.   +7 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Routine Frozen Section Analysis May Be Omittable for Nodular Basal Cell Carcinoma Undergoing Local Flap Reconstruction. [PDF]

Cancers (Basel)
Hansen MK, Topal M, Saltvig I, Alrasheed T, Mamsen FPW, Krezdorn N.   +5 more
europepmc   +1 more source

A Giant Basal Cell Carcinoma of the Scalp-A Clinical Case Study. [PDF]

Diagnostics (Basel)
Zagórska B, Rutkowski J, Kunc M, Żółkiewicz J, Maińska U, Sobjanek M, Sławińska M.   +6 more
europepmc   +1 more source

Confocal laser microendoscopy characterization of vascular features in facial basal cell carcinoma: a comparative analysis of tumor and adjacent healthy tissue. [PDF]

Lasers Med Sci
Müller-Diesing F, Sievert M, Aubreville M, Hackenberg S, Panuganti B, Klein M, Porsche N, Scherzad A, Stöth M, Winnand P, Wirth M, Goncalves M.   +11 more
europepmc   +1 more source

Treatment of Nodular Basal Cell Carcinoma With Topical 5% Imiquimod Cream: An Autobiographical Case Report. [PDF]

Cureus
Cohen PR.
europepmc   +1 more source