Results 41 to 50 of about 6,707,637 (199)

Long-term safety, tolerability, and efficacy of vismodegib in two patients with metastatic basal cell carcinoma and basal cell nevus syndrome

Dermatology Reports, 2011
Tumor responses in advanced basal cell carcinoma (BCC) have been observed in clinical trials with vismodegib, a SMO antagonist. The result of SMO antagonism is inhibition Hedgehog Signaling Pathway (HHSP) downstream target genes. HHSP inhibition has been
Glen J. Weiss, Raoul Tibes, Lisa Blaydorn, Gayle Jameson, Molly Downhour, Erica White, Ivor Caro, Daniel D. Von Hoff   +7 more
doaj   +1 more source

Ruptured and Inflamed Epidermal Inclusion Cyst of Tongue- A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2018
Epidermal inclusion cyst (EIC) is rare in head and neck region with incidence in oral cavity being less than 0.01%, presenting as congenital or as acquired lesions. Clinically patient presents with dysphagia, difficulty in breathing and may be associated
Nishant Sagar, Prerna Arora, Nita Khurana, JC Passey   +3 more
doaj   +1 more source

Thermal Injury Producing Melanoma‐Like Features on Reflectance Confocal Microscopy

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives Reflectance confocal microscopy (RCM) improves diagnostic specificity for equivocal pigmented lesions; however, certain conditions may mimic melanoma and limit its accuracy. We aimed to characterize RCM features of thermally injured lesions that mimic melanoma.
Noa Kremer, Isabella N. Dana, Miguel Cordova, Aditi Sahu, Cristian Navarrete‐Dechent, Ashfaq A. Marghoob   +5 more
wiley   +1 more source

Multiple keratocysts of the mandible in association with Gorlin-Goltz syndrome: A rare case report

Contemporary Clinical Dentistry, 2014
Nevoid basal cell carcinoma syndrome is a syndrome with wide variety of manifestations ranging from oral lesions to skeletal deformities. It calls for due responsibility of maxillofacial surgeon to diagnose the syndrome because very often they are the ...
Gayithri Harish Kulkarni, Shahanavaj I Khaji, Suryakant Metkari, Harish S Kulkarni, Reshma Kulkarni   +4 more
doaj   +1 more source

Mosaic KRAS Variant as a Cause of Developmental Eye Anomalies in an Individual With EncephaloCranioCutaneous Lipomatosis

Clinical Genetics, EarlyView.
We describe a girl presenting with structural eye anomalies and a constellation of features suggestive of the mosaic RASopathy EncephaloCranioCutaneous Lipomatosis (ECCL). Tissue‐specific investigations identified a mosaic KRAS variant at a mutational hotspot (p.[Ala146Pro]), prompting appropriate tumour surveillance.
Karthikah Jeganathan, Fabiola Ceroni, Samuel J. H. Clokie, Nicole Motton Hill, Manoj Parulekar, Karl Johnson, Lidiya V. Talbot, Dorine A. Bax, Nicola K. Ragge   +8 more
wiley   +1 more source

Eruptive Acral Melanocytic Lesions Associated With Capecitabine

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Eruptive nevi and lentigines have been reported to occur in the setting of immunosuppression, which may be medication‐induced. The associated histopathologic findings have not been well described in the literature. Herein, we report the case of a woman in her 60s who had been receiving chemotherapy treatment with capecitabine, a prodrug of 5 ...
Madison Smith, Annie Jin, Jonathan A. Miles, Rosalie Elenitsas, Danielle M. DeHoratius, Emily Y. Chu   +5 more
wiley   +1 more source

Prospective subtyping of head and neck basal cell carcinoma by dermoscopy and handheld RCM

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Handheld reflectance confocal microscopy, alone or with dermoscopy, increases specificity, maintains high sensitivity and improves diagnostic confidence for head and neck basal cell carcinoma. It may offer a non‐invasive alternative to confirmatory biopsies when planning micrographically controlled surgery in clinically high‐risk cases.
Yannick S. Elshot, Wouter Ouwerkerk, Biljana Zupan‐Kajcovski, Mijke Bol, Erienne M. V. de Cuba, Lies H. Jaspars, Giulia Briatico, Giuseppe Argenziano, Nicole A. Kukutsch, Salvador Gonzalez, Manu Jain, Marianne B. Crijns, Alfons J. M. Balm, W. Martin C. Klop, Marcel W. Bekkenk, Menno A. de Rie   +15 more
wiley   +1 more source

Study disposition.

, 2022
aBCC, advanced basal cell carcinoma; BCCNS, basal cell carcinoma nevus syndrome; HPI, Hedgehog pathway inhibitor; laBCC, locally advanced basal cell carcinoma; mBCC, metastatic basal cell carcinoma.
Simon Yoo (11949194), Aleksandar Sekulic (3192720), Laura Chu (1891477), Edward McKenna (4030052), Yong Mun (9200749), Julie Guillen (11949200), Ragini Kudchadkar (11949197), Gary Rogers (505210), Keith Dawson (11949209), Scott Guenthner (11949203), Mario Lacouture (11949212), Anne Lynn S. Chang (3339900), Bernard Raskin (11949206)   +12 more
core   +1 more source

Differential Diagnosis Performance of ChatGPT in Oral and Maxillofacial Pathology

Oral Diseases, EarlyView.
ABSTRACT Objective To evaluate ChatGPT (GPT‐5.1) for ranked differential diagnoses in oral and maxillofacial pathology, assess image effects on diagnostic performance and examine output stability across repeated runs. Methods This retrospective diagnostic accuracy study included 160 biopsy‐confirmed cases.
Sohaib Shujaat, Marryam Riaz, Jawaher Mohammed Alsubaie, Aljwhrah Abdulaziz Almuammar, Arun Pillai, Abdulmohsen Alfadley, Ali Anwar Aboalela   +6 more
wiley   +1 more source

Basal cell carcinoma and balloon cell nevus collision mimicking a melanoma on reflectance confocal microscopy. [PDF]

, 2023
A preexisting intradermal nevus (IDN) on the chest of a 30-year-old patient changed compared with her baseline total body photography. Clinical examination found a 6-mm shiny pink papule (Fig 1, inset).
Jain, Manu, Marghoob, Ashfaq A., Carrera Álvarez, Cristina   +2 more
core   +1 more source