Results 111 to 120 of about 559,417 (315)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Insulin glargine 300 U/mL for basal insulin therapy in type 1 and type 2 diabetes mellitus

Diabetes, Metabolic Syndrome and Obesity, 2017
Ip Tim Lau,1 Ka Fai Lee,2 Wing Yee So,3 Kathryn Tan,4 Vincent Tok Fai Yeung5 1Department of Medicine, Tseung Kwan O Hospital, 2Department of Medicine and Geriatrics, Kwong Wah Hospital, 3Department of Medicine and Therapeutics, Chinese University of Hong
Lau IT, Lee KF, So WY, Tan K, Yeung VTF
doaj  

Airway basal cells from human-induced pluripotent stem cells: a new frontier in cystic fibrosis research

Frontiers in Cell and Developmental Biology
Human-induced airway basal cells (hiBCs) derived from human-induced pluripotent stem cells (hiPSCs) offer a promising cell model for studying lung diseases, regenerative medicine, and developing new gene therapy methods.
Anna Demchenko, Lyubava Belova, Maxim Balyasin, Maxim Balyasin, Konstantin Kochergin-Nikitsky, Ekaterina Kondrateva, Ekaterina Voronina, Victoria Pozhitnova, Vyacheslav Tabakov, Diana Salikhova, Tatiana Bukharova, Dmitry Goldshtein, Elena Kondratyeva, Tatiana Kyian, Elena Amelina, Olga Zubkova, Olga Popova, Tatiana Ozharovskaia, Alexander Lavrov, Svetlana Smirnikhina   +19 more
doaj   +1 more source

Evidence-based medicine and the journal club: a cross-sectional survey of participants' views [PDF]

, 1997
James Warner, Micháel J. King
openalex   +1 more source

Carbon Particles in Melanocytes and Basal Cells as a Result of a Tattoo**From the Dermatopathology Laboratory, Boston City Hospital and the Department of Dermatology Tufts University School of Medicine, Boston, Mass.

Journal of Investigative Dermatology, 1965
The particles of a tattoo are found in the dermis, both within phagocytes and extracellularly. Little is known concerning the transport of foreign particles from the dermis, although there are several reports describing such material in the epidermis. Kochs (1) has described gold particles within epithelial cells in chrysiasis. In a case of paraffinoma
openaire   +3 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Treating avulsion fractures of the base of the fifth metatarsal. [PDF]

, 1999
Barbara J. Martin
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Steroids in De Quervain's tenosynovitis. [PDF]

, 1998
Angela Jones
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source