Results 171 to 180 of about 938,616 (362)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Regenerative Medicine for the Aging Brain [PDF]

, 2014
In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during ...
Goya, Rodolfo Gustavo, Hereñú, Claudia Beatriz, López León, Micaela, Reggiani, Paula Cecilia   +3 more
core   +2 more sources

An elective course for first-year students based on the New England Journal of Medicine

, 1988
O Griffith, Mary E. W. Goss, Kenneth Tardiff, E J Cassell, Joel D. Pardee, A WEINSTEIN   +5 more
openalex   +1 more source

Evidence-based medicine, user involvement and the post-modern paradigm [PDF]

, 1999
Richard Laugharne
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Meningococcal disease: -- A review based on a symposium held on 11 July 1992 at the Liverpool School of Tropical Medicine

, 1993
C. A. Hart, Thomas R. Rogers
openalex   +1 more source

Evidence based medicine [PDF]

, 1995
David A Fitzmaurice
openalex   +1 more source

HOMOEOPATHIC MEDICINES USED IN THE MANAGEMENT OF BASAL ROT OF ONION CAUSED BY FUSARIUM OXYSPORUM F. SP.CEPAE IN NASIK DISTRICT. [PDF]

International Journal of Advanced Research, 2017
JagtapJ D, NS Suryawanshi.
openaire   +2 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

All members of primary care team are aware of importance of evidence based medicine [PDF]

, 1998
Nicola A. Hagdrup, M Falshaw, Richard W. Gray, Y. Carter   +3 more
openalex   +1 more source