Results 11 to 20 of about 30,761,260 (406)
Proximity-Based Modalities for Biology and Medicine
ACS Central Science, 2023 Molecular proximity orchestrates biological function, and blocking existing proximities is an established therapeutic strategy. By contrast, strengthening or creating neoproximity with chemistry enables modulation of biological processes with high ...
Xingui Liu, A. Ciulli
semanticscholar +1 more source
An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine
Clinical pharmacology and therapy, 2021 Clinical annotations are one of the most popular resources available on the Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the association between variant‐drug pairs, shows relevant findings from the curated literature ...
Michelle Whirl‐Carrillo +6 more
semanticscholar +1 more source
Frontiers in Neuroscience, 2019 Teneurins (Tens) are a highly conserved family of proteins necessary for cell-cell adhesion. Tens can be cleaved, and some of their proteolytic products, such as the teneurin c-terminal associated-peptide (TCAP) and the intracellular domain (ICD), have ...
Sussy Bastías-Candia +7 more
doaj +1 more source
Generation of Choline for Acetylcholine Synthesis by Phospholipase D Isoforms [PDF]
, 2001 DEDICATION: This article is dedicated to the memory of Sue Kim Hanson, a graduate student in the department of Pathology and Laboratory Medicine at Boston University School of Medicine, who perished in the terrorist attacks of September 11, 2001 ...
Blusztajn, Jan Krzysztof +2 more
core +3 more sources
Long term in vitro expansion of epithelial stem cells enabled by pharmacological inhibition of PAK1-ROCK-Myosin II and TGF-β signaling [PDF]
, 2018 Summary: Despite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest.
Challberg, Sharon S +7 more
core +2 more sources
Joint and individual analysis of breast cancer histologic images and genomic covariates [PDF]
, 2020 A key challenge in modern data analysis is understanding connections between complex and differing modalities of data. For example, two of the main approaches to the study of breast cancer are histopathology (analyzing visual characteristics of tumors ...
Calhoun, Benjamin C. +10 more
core +3 more sources
Neurobiology of Disease, 2006 Intrastriatal transplants of embryonic ventral mesencephalon can cause dyskinesia in patients with Parkinson's disease (PD). We assessed the impact of transplant size on the development of graft-induced dyskinesia.
E.L. Lane +3 more
doaj +1 more source
Journal of Advanced Veterinary and Animal Research, 2018 Objective: The objective of the current study was to investigate the influence of probiotic Chrysonilia crassa in comparison with zinc bacitracin, commercial probiotic Bacillus subtilis, and herbal medicine waste on growth, intestinal microbiology, and ...
Sugiharto Sugiharto +5 more
doaj +1 more source
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2021 The artificial rapid propagation system for Swertia conaensis T. N. Ho et S. W. Liu was explored to screen the appropriate plant regeneration method and to provide an efficient propagation mode, useful for artificial breeding technology or for further research and development of the Tibetan endemic medicinal plant.
Yin-Kai XI, Heng-Yu HUANG
openaire +3 more sources
MRI and Neuropsychological Correlates of Carbon Monoxide Exposure: A Case Report [PDF]
, 2002 A 45-year-old woman experienced long-term, chronic exposure to carbon monoxide in the restaurant kitchen where she was employed as a cook. After returning to the restaurant after 5 days off work, she noticed that her symptoms returned immediately; she ...
Bunnell DE +9 more
core +3 more sources