Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
A Case Report of Multiple Odontogenic Keratocysts in Gorlin Syndrome
پزشکی بالینی ابن سینا, 2014 Introduction: Gorlin syndrome is a rare disorder with different diagnostic criteria such as mul-tiple odontogenic keratocysts, basal cell carcinomas, palmar ;plantar pits, frontal bossing and hypertelorism and calcification of falx cerebri.
Hamid Reza Abdolsamadi +3 more
doaj
Evidence-based medicine and the practicing clinician
, 1999 Finlay A. McAlister +3 more
openalex +2 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Effects of Supplementation of Boric Acid in Dietary and Drinking Water on Performance, Incubation Characteristic and Intestinal Microbiota in Different Quail Varieties (Coturnix coturnix japonica). [PDF]
Vet Med SciAslan S +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Expanding the Epidemiological and Phenotypic Spectrum of MEGDEL Syndrome: The First Case Report From Egypt. [PDF]
Clin Med Insights PediatrSadek AA +6 more
europepmc +1 more source
Epidemiology, Evidenced-Based Medicine, and Evidence-Based Public Health
, 1997 Milos Jenicek
openalex +2 more sources
Evidence-based medicine: challenging the orthodoxy [PDF]
, 1998 David G. Grahame‐Smith
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source