Results 251 to 260 of about 30,761,260 (406)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Higher basal ganglia perivascular space burden is associated with reduced deep medullary vein visibility via free water accumulation in sporadic cerebral small vessel disease. [PDF]

Eur J Med Res
Yu J, Lei X, Xu Z, Lan H, Wu Z.
europepmc   +1 more source

Revision of the Ovibovini Gill 1872 (Bovidae, Caprinae) through a cladistic analysis based on morphological characters [PDF]

, 2013
Fack, Fabrice, Wörheide, Gert
core   +1 more source

Principles of drug therapy for acute bacterial rhinosinusitis: from evidence-based medicine to practice

, 2018
D. S. Pshennikov, И. Б. Анготоева   +1 more
openalex   +1 more source

Student and educator perceptions of an evidence-based medicine research curriculum: recommendations for research curriculum development

, 2023
Dario Ferri, Clara Moore, Kyung Joon Mun, Anna Chen, Debra K. Katzman, Joyce Nyhof‐Young   +5 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Multi-platform analysis of the tumor immune microenvironment associated with breast cancer subtypes. [PDF]

Oncoimmunology
Torland LA, Geisler J, Azimzade Y, Frafjord A, Røed Nilsen H, Buer L, Lømo J, Garred Ø, Tahiri A, Lyngra M, Øynebråten I, Corthay A, Sahlberg K, Kristensen V, Tekpli X.   +14 more
europepmc   +1 more source

Evidence-Based Medicine : An Overview

, 2001
Kamlesh Bhargava, Roman Jaeschke
openalex   +2 more sources

Investigation of Possible Apocrine Gland Component in Basal Cell Epithelioma11From the University of Pennsylvania, Departments of Dermatology, School of Medicine and Graduate School of Medicine, Philadelphia, Pennsylvania.

Journal of Investigative Dermatology, 1958
Wood, Margaret Gray, Pranich, Kachorn, Beerman, Herman   +2 more
openaire   +1 more source

International Parkinson and movement disorder society evidence‐based medicine review: Update on treatments for the motor symptoms of Parkinson's disease

Movement Disorders, 2018
S. Fox, R. Katzenschlager, Shen-Yang Lim, B. Barton, R. D. de Bie, K. Seppi, M. Coelho, C. Sampaio   +7 more
semanticscholar   +1 more source