Results 301 to 310 of about 30,761,260 (406)

Left ventricular outflow tract obstruction following left bundle branch area pacing: a case report. [PDF]

Eur Heart J Case Rep
Lian X, Yang XM, Zhang R, Liu B, Li Y.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Impact of BMI on basal LH in premenarcheal girls with idiopathic central precocious puberty. [PDF]

Front Endocrinol (Lausanne)
Yuan X, Zhang Y, Zhang J, Wu W, Chen R.
europepmc   +1 more source

Register-based indicators for quality of prescribing and responsible use of medicines applicable in the Nordic countries: A systematic scoping review and Delphi study

Fatimah Fathy, Katri Aaltonen, Leena Saastamoinen, Hanna Rättö, Sofia Kälvemark-Sporrong, Per-Jostein Samuelsen, Piia Rannanheimo, Lotte Rasmussen, Bjorn Wettermark, Marja-Lisa Laukkonen   +9 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Fluid shear stress-dependent modulation of the basal endothelial glycocalyx. [PDF]

PLoS One
Vittum Z, Mensah SA.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cecal microbiota of broilers responds similarly to black soldier fly larvae fat and conventional dietary fat sources. [PDF]

PLoS One
Aslam MR, Kierończyk B, Szymkowiak P, Ciesielska L, Rawski M, Mikuła R, Józefiak D.   +6 more
europepmc   +1 more source

Knowledge, attitude and practices regarding generic medicines and its usage: a community-based study

, 2019
Kirthinath Ballala, Chythra R Rao, Aparna Sen Chaudhary, Ashwini Shivakumar Bidnurmath, Akhilesh Kumar Pandey   +4 more
openalex   +2 more sources