Results 241 to 250 of about 5,088,367 (309)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Antibiotic-Impregnated Calcium Sulfate Beads for Local Therapy of Severe Skull Base Osteomyelitis. [PDF]

Clin Case Rep
Lyutenski S, Henze A, James P, Bloching M.   +3 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Interpretable and extrapolation-stable model for predicting nanofluid thermal conductivity. [PDF]

Sci Rep
Zinhom E, Radwan SS, Elmasry A, Sharaf MAM, Nassar MM.   +4 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Peeking behind the carbocation: identification of (alternative) catalytic bases in the class II active site of conifer resin acid diterpene synthases. [PDF]

Biochem J
Raslan AMAA, Peters RJ.
europepmc   +1 more source

In Vitro Shear Bond Strength of Additively Manufactured Denture Base Resins to Hard Chairside Reline Materials. [PDF]

Int Dent J
Yoo JH, Kim J, Park Y, Kim JH.
europepmc   +1 more source

Research on the aging characteristics of base liquor in Sichuan Province's strong Aroma Baijiu at different aging periods using mass spectrometry and 3D fluorescence spectroscopy methods. [PDF]

PLoS One
He Q, Han G, Yao H, Wang J, Geng D, Han Q, Wang X, Tang K.   +7 more
europepmc   +1 more source

Economic resource impact statement fiscal year 1990

, 1990
Reese Airforce Base
core  

BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments. [PDF]

Genome Biol
Dinçer C, Fussing B, Garnett MJ, Coelho MA.   +3 more
europepmc   +1 more source