Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Experimental promoter identification of a foodborne pathogen Salmonella enterica subsp. enterica serovar Typhimurium with near single base-pair resolution. [PDF]
Front Microbiol, 2023 Lee SM +7 more
europepmc +1 more source
A Corpus-Based Approach to the Vocabulary Teaching and Learning—Implications From the Corpus-Based Collocational Research on Two Pairs of Synonyms [PDF]
, 2015 Yanhui Chen
openalex +1 more source
[Investigation of the mechanism of action and identification of candidate traditional Chinese medicines for the treatment of ischemic stroke in the Danshen-Jiangxiang pair based on drug-target-disease association network]. [PDF]
, 2023 Jiaxuan Gao, Yanrui Ding
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase. [PDF]
Nat Commun, 2023 Oh J +5 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
A Comprehensive Ab Initio Study of Halogenated A···U and G···C Base Pair Geometries and Energies. [PDF]
Int J Mol Sci, 2023 Gomila RM, Frontera A, Bauzá A.
europepmc +1 more source
Embedding Inquiry-Based Learning in a Large Database Course via Paired Assessment [PDF]
Mali Senapathi
openalex +1 more source