Results 171 to 180 of about 1,859,090 (336)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase. [PDF]

Nat Commun, 2023
Oh J, Kimoto M, Xu H, Chong J, Hirao I, Wang D.   +5 more
europepmc   +1 more source

A Simulation-based Approach on Robust Airline Job Pairing [PDF]

, 2012
Patrick Kuckertz, Oliver Ullrich, Hubert Randerath   +2 more
openalex   +1 more source

Effects of individual base-pairs on in vivo target search and destruction kinetics of small RNA [PDF]

, 2020
Anustup Poddar, Muhammad S. Azam, Tunc Kayikcioglu, Maksym Bobrovskyy, Jichuan Zhang, Xiangqian Ma, Piyush Labhsetwar, Jingyi Fei, Digvijay Singh, Zaida Luthey‐Schulten, Carin K. Vanderpool, Taekjip Ha   +11 more
openalex   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A Comprehensive Ab Initio Study of Halogenated A···U and G···C Base Pair Geometries and Energies. [PDF]

Int J Mol Sci, 2023
Gomila RM, Frontera A, Bauzá A.
europepmc   +1 more source

A Clustering-Based Approach to Kinetic Closest Pair

, 2016
Timothy M. Chan, Zahed Rahmati
openalex   +2 more sources

A Corpus-Based Approach to the Vocabulary Teaching and Learning—Implications From the Corpus-Based Collocational Research on Two Pairs of Synonyms [PDF]

, 2015
Yanhui Chen
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Nucleic acid base pair open states by hydrogen exchange. [PDF]

Proc Natl Acad Sci U S A
Englander SW.
europepmc   +1 more source