Results 191 to 200 of about 446,496 (303)

Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation. [PDF]

Nucleic Acids Res
Lin SM, Huang HT, Fang PJ, Chang CF, Satange R, Chang CK, Chou SH, Neidle S, Hou MH.   +8 more
europepmc   +1 more source

Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II. [PDF]

Nat Chem Biol, 2021
Oh J, Shin J, Unarta IC, Wang W, Feldman AW, Karadeema RJ, Xu L, Xu J, Chong J, Krishnamurthy R, Huang X, Romesberg FE, Wang D.   +12 more
europepmc   +1 more source

Comparison of Efficacy and Willingness to a 5% Gluconolactone‐Based Topical Serum and Intense Pulsed Light in Mild Erythema of Rosacea: A Paired Control Study [PDF]

Yiran Peng, Mengping Mao, Ziyang Huang, Huimin Zhao, Ying Li, Dan Jian   +5 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

HideRNAs protect against CRISPR-Cas9 re-cutting after successful single base-pair gene editing. [PDF]

Sci Rep, 2022
Harmsen TJW, Pritchard CEJ, Riepsaame J, van de Vrugt HJ, Huijbers IJ, Te Riele H.   +5 more
europepmc   +1 more source

A Population-based Study of Bronchial Asthma in Adult Twin Pairs [PDF]

, 1992
David L. Duffy
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations. [PDF]

Clin Epigenetics
Li JS, Riggins K, Yang L, Chen C, Castro P, Alfarkh W, Zarrin-Khameh N, Scheurer ME, Creighton CJ, Musher B, Li W, Shen L.   +11 more
europepmc   +1 more source

preciseTAD: a transfer learning framework for 3D domain boundary prediction at base-pair resolution. [PDF]

Bioinformatics, 2022
Stilianoudakis SC, Marshall MA, Dozmorov MG.   +2 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source