Results 171 to 180 of about 353,589 (332)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences. [PDF]
Genome Biol, 2023 Bergeron D +12 more
europepmc +1 more source
How do base-pairing small RNAs evolve? [PDF]
, 2015 Taylor B. Updegrove +2 more
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation. [PDF]
Cell Rep Methods, 2022 Isiktas AU, Eshov A, Yang S, Guo JU.
europepmc +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Unusual Base-Pairing Interactions in Monomer–Template Complexes
ACS Central Science, 2016 Wen Zhang +3 more
doaj +1 more source
Discriminative projective dictionary pair based broad metric learning system: algorithm and its applications in pattern classification [PDF]
Junwei Duan, Yutong Zou
openalex +1 more source
A Population-based Study of Bronchial Asthma in Adult Twin Pairs [PDF]
, 1992 David L. Duffy
openalex +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source