Results 91 to 100 of about 20,204 (286)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Analysis of ecological prevention and control technology for expansive soil slope

Frontiers in Earth Science
For the expansion soil slope in the JiangHuai area before the disposal of the neglect of expansion of the weak defects and slope disposal after the poor long-term stability of the current situation. This study investigates the ability of ecological slope
Wenbing Tao, Yingwen Wen, Yingwen Wen, Xia Bian, Zhilin Ren, Long Xu, Fei Wang, Hu Zheng   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Optimal Resource Allocation in Relay-Assisted ISAC Systems via Deep Reinforcement Learning

IEEE Open Journal of the Communications Society
This article studies joint beamforming and power allocation in a full-duplex decode-and-forward (FD-DF) relay-assisted monostatic integrated sensing and communication (ISAC) system. The base station performs monostatic sensing in the presence of clutter,
Hamidreza Hojjati, Ali Rezapour, S. Mohammad Razavizadeh   +2 more
doaj   +1 more source

Étude des interactions mécaniques et physico-chimiques entre les argiles et les fluides de forage. Application à l'argile de Boom (Belgique) A Study O the Mechanical and Physicochemical Interactions Between the Clay Materials and the Drilling Fluids. Application to the Boom Clay (Belgium)

Oil & Gas Science and Technology, 2006
Ce travail est motivé par les problèmes posés par la stabilité des puits forés dans des formations argileuses avec des boues de forage à base d'eau. En effet, les roches argileuses ou argilites (shales en anglais) ont la propriété d'absorber de l'eau ...
Tshibangu J. P., Sarda J. P., Audibert-Hayet A.   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Long-term probabilistic forecasts of activity mitigation in English hospitals: a national elicitation exercise providing an outside view based on judgements of experts in support of the New Hospital Programme

BMJ Open
Objectives The planning process for a new hospital relies on assumptions about future levels of demand. Typically, such assumptions are characterised by point estimates, the flaw-of-averages, base-rate neglect and overoptimism from an inside view.
Mohammed A Mohammed, Steven Wyatt, Thomas Jemmett, Josh Cook, Jake Parsons, Chris Beeley, Peter Spilsbury   +6 more
doaj   +1 more source

Numeracy Predicts Susceptibility to Base Rate Neglect, Probability Matching, and Ratio Bias

, 2020
Ryan Corser
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source