Results 131 to 140 of about 8,939,565 (239)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The development of heuristics in children: Base-rate neglect and representativeness.
, 2016 This paper examines the development of therepresentativeness heuristic in early childhood. Using a novelparadigm, we investigated 3- to 6-year-old children’s abilityto use base-rate and individuating information in theirpredictive inferences. In Experiment 1, we presented childrenwith base-rate and individuating information separately to testtheir ...
Gualtieri, Samantha, Denison, Stephanie
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Re-Examining Base-Rate Neglect: The Effect Of Context. [PDF]
Classic base-rate neglect studies have been consistently criticised for lacking ecological validity. A study by Welsh & Navarro (2012) found this heuristic was significantly reduced when participants perceived the base rate as more relevant. The present study aims to study this phenomenon through a more realistic scenario while simultaneously ...
Adler, Nine, Dewitt, Stephen H
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Transcript of Commission to Eliminate Child Abuse and Neglect Fatalities Hearing: October 30, 2015
, 2015 Transcript of a public teleconference held by the Commission to Eliminate Child Abuse and Neglect Fatalities (CECANF) on October 30, 2015. This hearing includes opening remarks by Chairman Sanders and a discussion by the Commission on parts of the early ...
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Transcript of Commission to Eliminate Child Abuse and Neglect Fatalities Hearing: February 15, 2016
, 2016 Transcript of a public teleconference held by the Commission to Eliminate Child Abuse and Neglect Fatalities (CECANF) on February 15, 2016.
CQ Transcriptions
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