Results 211 to 220 of about 887,234 (267)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

miR828 positively regulates proanthocyanidin accumulation in sainfoin (Onobrychis viciifolia). [PDF]

BMC Plant Biol
Li W, Xie X, Dai S, Yan Y, Liu Y, Yuan F, Liang Y, Yue S, Xiao S, Yi D, Li J, Nan L, Jiang W.   +12 more
europepmc   +1 more source

Mini-Hairpin DNA: Extraordinarily Stable Structure and Its Applications. [PDF]

Chemistry
Kimoto M, Hirao I.
europepmc   +1 more source

Iterative design of a NAND hybrid riboswitch by deep batch Bayesian optimization. [PDF]

Nucleic Acids Res
Kelvin D, Kubaczka E, Karava M, Koeppl H, Suess B.   +4 more
europepmc   +1 more source

How Does Transcription-Associated Mutagenesis Shape tRNA Microevolution? [PDF]

Genome Biol Evol
Baños H, Wang L, Simonti C, Paaby AB, Heitsch C.   +4 more
europepmc   +1 more source

EnDeep4mC predicts DNA <i>N</i> ⁴-methylcytosine sites using a dual-adaptive feature encoding framework in deep ensembles. [PDF]

Genome Res
Zhang S, Zou Q, Niu M, Lv Z, Stalin A, Luo X.   +5 more
europepmc   +1 more source

Recognition of Non-standard Base Pairs by Triplex-Forming Oligonucleotides Containing an Expanded Genetic Alphabet

Rusling D, Brazzill M, Ma R, Munn K, Prestifilippo L, Pickford A, Kim H, Chen C, Hoshika S, Benner S.   +9 more
europepmc   +1 more source