Results 41 to 50 of about 28,959,149 (302)

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li   +6 more
wiley   +1 more source

Temporal Scale Effects on Daily Sediment Yield in the Fu River Basin

open access: yesShuitu Baochi Xuebao
[Objective] To analyze the scale-dependent relationships between daily sediment yield and key environmental factors and to explore effective prediction method to cope with the prediction challenges caused by the complexity of sediment transport ...
XU Yaotao   +6 more
doaj   +1 more source

Efficient 3-D placement of an aerial base station in next generation cellular networks [PDF]

open access: yes2016 IEEE International Conference on Communications (ICC), 2016
Agility and resilience requirements of future cellular networks may not be fully satisfied by terrestrial base stations in cases of unexpected or temporary events.
R. Irem   +3 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Age Structure and Spatial Distribution Pattern of Rubber Tapping Labor Force in Hainan Island

open access: yesRedai dili
Currently, tapping is the only method of obtaining natural rubber, an essential industrial raw material. The stability of the labor force supply for tapping is crucial for the sustainable development of the natural rubber industry.
Wang Guizhen   +5 more
doaj   +1 more source

DRAG: Deep Reinforcement Learning Based Base Station Activation in Heterogeneous Networks [PDF]

open access: yesIEEE Transactions on Mobile Computing, 2018
Heterogeneous Network (HetNet), where Small cell Base Stations (SBSs) are densely deployed to offload traffic from macro Base Stations (BSs), is identified as a key solution to meet the unprecedented mobile traffic demand.
Junhong Ye, Y. Zhang
semanticscholar   +1 more source

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