Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
K2CO3-catalyzed highly efficient O and N-acylation under mild conditions
Tetrahedron Green ChemAn eco-friendly, mild and efficient acylation of various nucleophiles with alkenyl carboxylates via inorganic base catalysis is described. Among five inorganic base species examined, K2CO3 was proved to be the most efficient catalyst for the acylation. A
Haiyang Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Modelling and Validation of Computer Vision Techniques to Assess Heart Rate, Eye Temperature, Ear-Base Temperature and Respiration Rate in Cattle. [PDF]
Animals (Basel), 2019 Jorquera-Chavez M +5 more
europepmc +1 more source
Development of dispersion strengthened tantalum base alloy Quarterly progress report, Nov. 20, 1966 - Feb. 20, 1967 [PDF]
Grain size and annealing temperature effects on creep properties of dispersion strengthened tantalum base ...
Buckman, R. W., Jr., Goodspeed, R. C.
core +1 more source
Prediction of Wind Turbine Gearbox Oil Temperature Based on Stochastic Differential Equation Modeling [PDF]
Hongsheng Su +2 more
openalex +1 more source
Temperature Prediction Model for a Regenerative Aluminum Smelting Furnace by a Just-in-Time Learning-Based Triple-Weighted Regularized Extreme Learning Machine [PDF]
, 2022 Xingyu Chen, Jiayang Dai, Yasong Luo
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source