Results 91 to 100 of about 4,238,003 (295)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad   +22 more
wiley   +1 more source

Topology Choice and Optimization of a Bearingless Flux-Switching Motor with a Combined Winding Set

open access: yesMachines, 2018
The purpose of this paper is to choose a new topology for bearingless flux-switching slice motors, regarding the number of stator and rotor poles, with a combined winding set.
Vedran Jurdana   +2 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno   +19 more
wiley   +1 more source

Cardinalities of topologies with small base

open access: yesAnnals of Pure and Applied Logic, 1994
Let T be the family of open subsets of a topological space (not necessarily Hausdorff or even T_0). We prove that if T has a base of cardinality <= mu, lambda <= mu < 2^lambda, lambda strong limit of cofinality aleph_0, then T has cardinality <= mu or >= 2^lambda. This is our main conclusion.
openaire   +3 more sources

Analyzing Some Structural Properties of Topological B-Algebras

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2019
In this study, we investigate the topology on B-algebras: an algebraic system of propositional logic. We define here the notion of topological B-algebras (briefly, TB-algebras) and some properties are investigated. A characterization of TB-algebras based
Narciso C. Gonzaga
doaj   +1 more source

The Topology of Spaces of Polygons [PDF]

open access: yes, 2011
We study the topology of spaces of polygons in Euclidean space, viewed up to translations. The main results concern the structure of the homology groups and of the cohomology rings of the spaces.
FROMM, VIKTOR
core  

On the Role of Topology in Focus+Context Visualization

open access: yes, 2007
In this paper three types of visualization scenarios are discussed, where topology improves the readability of particular visualization results. The rst type combines topology information represented by simple graphical primitives with other forms of ...
Gröller, Eduard, Viola, Ivan
core   +4 more sources

Modular Critical Element Recycling Platform Using a Nanoporous Additively Manufactured Gyroid

open access: yesAdvanced Engineering Materials, EarlyView.
A modular recycling platform integrates 3D‐printed nanoporous gyroid structures to enable efficient critical element recovery. This system utilizes a hierarchical architecture, combining macroscopic channels with polymerization‐induced nanoscale porosity. By systematically tuning structural wall thickness and resin formulation, the platform achieves an
Xiangyu Gao   +6 more
wiley   +1 more source

Digital topologies revisited: An approach based on the topological point-neighbourhood [PDF]

open access: yes, 1993
Adopting the point-neighbourhood definition of topology, which we think may in some cases help acquire a very good insight of digital topologies, we unify the proof technique of the results on 4-connectedness and on 8-connectedness in ℤ2. We also show that there is no topology compatible with 6-connectedness. We shortly comment on potential further use
Pavel Pták   +2 more
openaire   +2 more sources

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