Results 251 to 260 of about 29,271,093 (298)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Approaches to teaching evidence-based medicine in residency: a systematic review. [PDF]

Med Educ Online
Mathieson K, Weemer M, Lipke L.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Effectiveness of Homoeopathic Treatments for Sleep Disorders in Children and Adolescents: A Systematic Review According to the Principles of Evidence-Based Medicine. [PDF]

Children (Basel)
Upreti K, Frass M.
europepmc   +1 more source

Single-Authored Systematic Reviews and Meta-Analyses: A Bibliometric Analysis of Trends and Alignment with Evidence-Based Medicine Guidelines. [PDF]

J Multidiscip Healthc
Shamsi A, Wang T, Bai T, Kadkhodaei Z, Heidari H, Dakhesh S.   +5 more
europepmc   +1 more source

Natural Language Processing in Support of Evidence-based Medicine: A Scoping Review. [PDF]

Find ACL ACL
Xu Z, Ma H, Zhang G, Ding Y, Weng C, Peng Y.   +5 more
europepmc   +1 more source

Critique on "Evaluation of Sex-Based Differences in the Prescription of the Combination of Evidence-Based Medicine After the Occurrence of an Acute ST-Elevation Myocardial Infarction". [PDF]

Clin Cardiol
Naseer M, Haider S, Rehman T.
europepmc   +1 more source

Impact of a combined case-based and evidence-based medicine teaching approach in traditional Chinese orthopedic residency training: a single-center, retrospective educational study. [PDF]

Front Med (Lausanne)
Zhang Y, Zeng Y.
europepmc   +1 more source

Maltreatment-Exposure Screening and Adolescent Mental Health: An Evidence-Based Medicine Perspective on Accuracy and Fairness. [PDF]

J Child Adolesc Trauma
Choi JW, Cohen JR.
europepmc   +1 more source