Results 271 to 280 of about 3,123,368 (386)

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

open access: yesAdvanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna   +9 more
wiley   +1 more source

Geometry Controls Confined Water Dynamics in Lipidic Mesophases

open access: yesAngewandte Chemie, EarlyView.
An archaeal‐inspired lipidic mesophase allows precise control of interfacial curvature and water‐channel connectivity. Combining structural, thermodynamic, and ultrafast spectroscopies, we reveal that curvature governs the structure and reorientation dynamics of confined water, establishing a molecular‐level link between topology and dynamics in soft ...
Sara Catalini   +7 more
wiley   +2 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari   +5 more
wiley   +1 more source

Unexpected Dual Function of Plant YUCCA Enzymes Links Chlorophyll Catabolism to Auxin Homeostasis

open access: yesAngewandte Chemie, EarlyView.
YUCCA enzymes are well known to catalyze the main step of auxin biosynthesis in plants. Here, a hitherto undescribed dual function was discovered, revealing that some YUCCAs also act in chlorophyll degradation. In vitro feedback regulation furthermore suggests a link between chlorophyll degradation and hormone homeostasis and a physiological role of ...
Sina Rütschlin   +6 more
wiley   +2 more sources

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