Results 71 to 80 of about 48,680 (261)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Land instability Compounds the risk of sea level rise in Alexandria, Egypt
International Journal of Applied Earth Observations and GeoinformationThe coastal region of Alexandria Governorate in Egypt holds significant strategic importance for trade while being susceptible to extreme weather events. It confronts a dual challenge of the rising sea levels and, as found in this study, land instability.
Rejoice Thomas +9 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Design of an Underwater Binocular Camera System for Intelligent Operations of Deep-Sea Robots
Kongzhi Yu Xinxi JishuUnderwater binocular camera systems are critical for enabling intelligent operations by deep-sea robots. They capture high-resolution underwater images and obtain accurate 3D data, providing the foundation for advanced autonomous functions, such as ...
ZHANG Dinhua, HUANG Zhong, YANG Mingyuan
doaj
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Journal of Marine Science and Engineering, 2018 This paper presents the design of a linear quadratic (LQ) optimal controller for a spar-type floating offshore wind turbine (FOWT). The FOWT is exposed to different sea states and constant wind turbulence intensity above rated wind speed.
Roberto Luiz Ramos
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Detection of Philippine Sea Plate Motion by very long baseline interferometry
Geophysical Research Letters, 1991 The Geographical Survey Institute (GSI) deployed a mobile Very Long Baseline Interferometry (VLBI) system at an established site in Chichijima (the biggest island in the Bonin islands), twice in an interval of two years. Two sessions were conducted in the experiments each year by connecting the reference base station at Kashima Space Research Center of
Shigeru Matsuzaka +4 more
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source